Umbilical cord plasma interleukin-6 concentrations in preterm infants and risk of neonatal morbidity - 25/08/11
Abstract |
Objective |
This study was undertaken to evaluate the association between umbilical cord interleukin-6 (IL-6) levels and neonatal morbidity in infants born at less than 32 weeks' gestation.
Study design |
Umbilical cord plasma IL-6 levels and neonatal outcomes were assessed in 309 infants born between 24 weeks and 0 days' and 31 weeks and 6 days' gestation.
Results |
Mean IL-6 levels were higher in spontaneous (n=193, 355 ± 1822 pg/mL) compared with indicated preterm births (n=116, 37 ± 223 pg/mL, P < .0001). Adjusting for gestational age, a progressive relationship was noted between increasing IL-6 levels and increased risk of neonatal systemic inflammatory response syndrome (SIRS). IL-6 levels beyond the 90th percentile (≥516.6 pg/mL) were also significantly associated with periventricular leukomalacia (PVL; odds ratio [OR] 15, 95% CI 2-149) and necrotizing enterocolitis (NEC; OR 6, 95% CI 1.1-33). In the multivariate analysis, an IL-6 level 107.7 pg/mL or greater (determined by receiver operating curve analysis) remained a significant independent risk factor for PVL (OR 30.3, 95% CI 4.5-203.6).
Conclusion |
Umbilical cord IL-6 levels are higher in preterm infants born after spontaneous preterm labor or premature rupture of membranes. Elevated IL-6 levels are associated with an increased risk for SIRS, PVL, and NEC in infants born at less than 32 weeks' gestation.
Le texte complet de cet article est disponible en PDF.Key words : Interleukin-6, Preterm labor, Neonatal morbidity, Neonatal systemic inflammatory response syndrome, Periventricular leukomalacia
Plan
| Supported by the National Institute for Child Health and Human Development P01 HD 33927 and K12 HD01258. Presented at the Twenty-Fourth Annual Meeting of the Society for Maternal-Fetal Medicine, February 2-7, 2004, New Orleans, La. Reprints not available from the authors. |
Vol 191 - N° 4
P. 1375-1381 - octobre 2004 Retour au numéro
Article précédent
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