Efficacy of the selective prostaglandin synthase type 2 inhibitor nimesulide in blocking basal prostaglandin production and delaying glucocorticoid-induced premature labor in sheep - 08/09/11
Abstract |
Objective: The purpose of the study was to determine the effects of selective prostaglandin synthase type 2 inhibitors on basal prostaglandin concentrations in the fetal and maternal circulations and on the labor-associated increase in prostaglandin production in sheep. Study Design: The effects of maternal nimesulide (0.01, 0.1, and 1 mg/kg) and 6-methoxy-2-naphthylacetic acid (1, 5, and 10 mg/kg) administration were examined (n = 5) at 134 ± 1 days’ gestation. At 138 days’ gestation premature labor was induced by fetal dexamethasone infusion (1 mg/d). Ewes were treated with either vehicle or nimesulide infusion (20 mg · d–1 · kg–1 , n = 5 per group). Results: Nimesulide and 6-methoxy-2-naphthylacetic acid decreased basal prostaglandin production in a concentration-dependent manner. Delivery of nimesulide-treated ewes was delayed by ≥17 hours with respect to that of control ewes (53.9 ± 2.6 hours). In 2 nimesulide-treated ewes labor did not progress to delivery despite membrane rupture. The increase in prostaglandin concentrations usually seen during dexamethasone-induced labor was abolished in nimesulide-treated ewes and also in their fetuses. Conclusions: Highly selective inhibitors of prostaglandin endoperoxidase H synthase 2 may be required to spare fetal prostaglandin production and limit potential side effects during the suppression of preterm labor. (Am J Obstet Gynecol 1999;180:1244-53.)
Le texte complet de cet article est disponible en PDF.Keywords : Labor, nimesulide, prostaglandin, prostaglandin endoperoxidase H synthase, sheep
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Supported by the National Health and Medical Research Council of Australia. |
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Reprint requests: Jonathan J. Hirst, PhD, Department of Physiology, Monash University, Clayton, Victoria, 3168, Australia. |
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0002-9378/99 $8.00 + 0 6/1/96881 |
Vol 180 - N° 5
P. 1244-1253 - mai 1999 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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