The effect of ovulation induction on the concentration of maternal serum relaxin in twin pregnancies - 12/09/11
Abstract |
OBJECTIVE: Our purpose was to determine the effects of fetal number, various ovulation induction treatments, and placental hormones on the concentration of maternal serum relaxin. STUDY DESIGN: The concentrations of relaxin, human chorionic gonadotropin, estriol, and ⍺-fetoprotein were determined in blood samples drawn at 16 to 18 weeks for prenatal diagnosis in 72 singleton and 115 twin pregnancies and analyzed by one-way analysis of variance, correlation analysis, and stepwise multiple linear regression of the log-transformed data. RESULTS: The maternal serum concentrations of each of the four measured hormones were significantly higher in the twin pregnancies than in the singleton pregnancies: 1.4-fold for relaxin, 1.9-fold for human chorionic gonadotropin, 1.9-fold for estriol, and 2.2-fold for ⍺-fetoprotein (all p < 0.01). The concentrations of each of the four hormones were significantly correlated with each of the others and with the number of fetuses (p < 0.01), except that estriol was not significantly correlated with human chorionic gonadotropin. The serum relaxin concentration in twin pregnancies after treatment with follicle-stimulating hormone and luteinizing hormone (menotropins) (n = 10) was 3.3-fold that in twins resulting from spontaneous ovulation (n = 89, p < 0.01). In twins resulting from in vitro fertilization or gamete intrafallopian transfer (n = 9) the serum relaxin concentration was 2.6-fold higher than in twins resulting from spontaneous ovulation (p < 0.01). The effect of clomiphene citrate (1.2-fold, n = 7) failed to reach statistical significance. CONCLUSIONS: The second fetus causes a 1.4-fold increase in the concentration of maternal serum relaxin in twin pregnancies. Induction of ovulation with menotropins causes an additional 3.3-fold increase, whereas in vitro fertilization or gamete intrafallopian transfer treatment causes an additional 2.6-fold increase over that seen in twin pregnancies that followed spontaneous ovulation. (AM J OBSTET GYNECOL 1996;174:227-32.)
Le texte complet de cet article est disponible en PDF.Keywords : Relaxin, follicle-stimulating hormone, estriol, ⍺-fetoprotein, twins
Plan
From the Departments of Obstetrics and Gynecologya and Pathology,b Brown University at Women and Infants' Hospital, and the Department of Obstetrics and Gynecology, New Jersey Medical School.c |
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Supported in part by National Institutes of Health grant No. R01 HD 22338. |
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Reprint requests: Jacob A. Canick, PhD, Department of Obstetrics and Gynecology, Women and Infants' Hospital, 101 Dudley St., Providence, RI 02905. |
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0002-9378/96 $5.00 + 0 6/1/66060 |
Vol 174 - N° 1P1
P. 227-232 - janvier 1996 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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