Analgesic and anti-inflammatory activity of alcoholic extract of stem bark of Pongamia pinnata (L.) Pierre
Sachin L. Badole, Anand A. Zanwar, Arvindkumar E. Ghule, Pinaki Ghosh, Subhash L. Bodhankar 
Abstract
Pongamia pinnata (L.) Pierre popularly known as ‘Karanj’ or ‘Karanja’ in Hindi, Indian beech in English is a medium-sized glabrous tree. The objective of the present investigation was to evaluate analgesic and anti-inflammatory activity of PPSBAE in laboratory animals. Analgesic activity was carried out by acetic acid-induced abdominal writhing and hot plate test in mice at the dose level of 100, 300 and 1000mg/kg. Anti-inflammatory activity was carried out by carrageenan (acute) and cotton pellet granuloma (chronic) tests in rats. Serum TNF-⍺ and IL-1β were measured by ELISA. The observed results suggested the PPSBAE showed significant analgesic and anti-inflammatory activity. PPSBAE decreased serum TNF-⍺ and IL-1β in acute as well as chronic anti-inflammatory studies.
Keywords : Analgesic, Anti-inflammatory, Pongamia pinnata, ELISA, TNF-⍺, IL-1β
Plan
Vol 2 - N° 1
P. 19-23 - janvier 2012 Retour au numéro
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