Nutrient sensor–mediated programmed nonalcoholic fatty liver disease in low birthweight offspring - 27/09/12
Résumé |
Objective |
We hypothesized that gestationally programmed nonalcoholic fatty liver disease in low-birthweight offspring is mediated through nutrient sensors nicotinamide adenine dinucleotide+–dependent histone deacetylase (SIRT1) and AMP-activated protein kinase (AMPK).
Study Design |
Pregnant dams received ad libitum food or were 50% food restricted from pregnancy days 10-21 to produce control and low-birthweight newborn offspring, respectively. All pups were nursed by control dams and weaned to ad libitum feed. We determined hepatic SIRT1 and AMPK activities and protein expression of lipid targets in low-birthweight and control fetuses, newborns, and adult offspring (3 months).
Results |
Low-birthweight fetuses demonstrated increased prenatal hepatic SIRT1 activity, although with increased lipogenesis. After birth, low-birthweight newborn offspring undergo postnatal suppression of hepatic SIRT1 and AMPK activities in conjunction with increased lipogenesis, decreased lipolysis, and increased fat stores.
Conclusion |
These findings suggest that undernutrition stress in utero may program hepatic nutrient sensors to perceive normal postnatal nutrition as a state of nutrient excess with the induction of hepatic lipid storage.
Le texte complet de cet article est disponible en PDF.Key words : lipogenesis, lipolysis, nutrient/metabolic sensors, programmed fatty liver
Plan
Supported by National Institutes of Health grants R01DK081756 and R01HD054751. |
|
The authors report no conflict of interest. |
|
Cite this article as: Wolfe E, Gong M, Han G, et al. Nutrient sensor–mediated programmed nonalcoholic fatty liver disease in low birthweight offspring. Am J Obstet Gynecol 2012;207:308.e1-6. |
Vol 207 - N° 4
P. 308.e1-308.e6 - octobre 2012 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?