First-trimester metabolomic detection of late-onset preeclampsia - 21/12/12
Résumé |
Objective |
We sought to identify first-trimester maternal serum biomarkers for the prediction of late-onset preeclampsia (PE) using metabolomic analysis.
Study Design |
In a case-control study, nuclear magnetic resonance–based metabolomic analysis was performed on first-trimester maternal serum between 11+0-13+6 weeks of gestation. There were 30 cases of late-onset PE, ie, requiring delivery ≥37 weeks, and 59 unaffected controls. The concentrations of 40 metabolites were compared between the 2 groups. We also compared 30 early-onset cases to the late-onset group.
Results |
A total of 14 metabolites were significantly elevated and 3 significantly reduced in first-trimester serum of late-onset PE patients. A complex model consisting of multiple metabolites and maternal demographic characteristics had a 76.6% sensitivity at 100% specificity for PE detection. A simplified model using fewer predictors yielded 60% sensitivity at 96.6% specificity. Strong separation of late- vs early-onset PE groups was achieved.
Conclusion |
Significant differences in the first-trimester metabolites were noted in women who went on to developed late-onset PE and between early- and late-onset PE.
Le texte complet de cet article est disponible en PDF.Key words : metabolomics, preeclampsia prediction
Plan
| This study was partly supported by a grant from the Fetal Medicine Foundation, Charity Number 1037116. |
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| The authors report no conflict of interest. |
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| Reprints not available from the authors. |
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| Cite this article as: Bahado-Singh RO, Akolekar R, Mandal R, et al. First-trimester metabolomic detection of late-onset preeclampsia. Am J Obstet Gynecol 2013;208:58.e1-7. |
Vol 208 - N° 1
P. 58.e1-58.e7 - janvier 2013 Retour au numéro
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