Oral disease in relation to future risk of dementia and cognitive decline: Prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial - 15/01/13

Doi : 10.1016/j.eurpsy.2011.07.005

G.-D. Batty ^a,^⁎,^b,^c,^d , Q. Li ^b, R. Huxley ^b, S. Zoungas ^b,^e, B.-A. Taylor ^f, B. Neal ^b, B. de Galan ^b,^g, M. Woodward ^b,^h, S.-B. Harrap ⁱ, S. Colagiuri ^j, A. Patel ^b, J. Chalmers ^b
On behalf of the ADVANCE Collaborative group
^a Department of Epidemiology and Public Health, University College of London, Torrington Place, London, UK
^b The George Institute for International Health, University of Sydney, Sydney, Australia
^c Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
^d Medical Research Council Social and Public Health Sciences Unit, Glasgow, UK
^e School of Public Health, Monash University, Melbourne, Australia
^f Department of Oral Biology, University of Oslo, Oslo, Norway
^g Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
^h Mount Sinai School of Medicine, New York, United States
ⁱ Department of Physiology, University of Melbourne, Melbourne, Australia
^j Institute of Obesity, Nutrition and Exercise, University of Sydney, Sydney, Australia

Corresponding author.

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Abstract

Objective

Examine the association of oral disease with future dementia/cognitive decline in a cohort of people with type 2 diabetes.

Methods

A total of 11,140 men and women aged 55–88 years at study induction with type 2 diabetes participated in a baseline medical examination when they reported the number of natural teeth and days of bleeding gums. Dementia and cognitive decline were ascertained periodically during a 5-year follow-up.

Results

Relative to the group with the greatest number of teeth (more than or equal to 22), having no teeth was associated with the highest risk of both dementia (hazard ratio; 95% confidence interval: 1.48; 1.24, 1.78) and cognitive decline (1.39; 1.21, 1.59). Number of days of bleeding gums was unrelated to these outcomes.

Conclusions

Tooth loss was associated with an increased risk of both dementia and cognitive decline.

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Keywords : Cognitive decline, Cohort study, Dementia, Oral disease

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Vol 28 - N° 1

P. 49-52 - janvier 2013 Retour au numéro

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Oral disease in relation to future risk of dementia and cognitive decline: Prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial - 15/01/13

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