Antihyperlipidemic effect of coumarin in experimental type 2 diabetic rats - 30/05/14
, Narayanasamy Rajarajeswari, Settu Saravanan, Ayyasamy RathinamAbstract |
The present study was aimed to examine the hypolipidemic effect of coumarin on streptozotocin–nicotinamide induced type 2 diabetic rats. Diabetes mellitus was induced by single intraperitoneal injection of 45mg/kg streptozotocin, 15min after the intraperitoneal administration of 110mg/kg nicotinamide. Streptozotocin–nicotinamide induced diabetic rats showed a significant increase in the levels of plasma and tissue (liver and kidney) lipids (total cholesterol, triglycerides, free fatty acids, phospholipids), LDL, VLDL and a significant decrease in the levels of HDL were observed. A significant increase in the activity of HMG-CoA reductase in tissues and significant decrease in the activities of LPL and LCAT in plasma were observed in type 2 diabetic rats. After oral administration of coumarin to diabetic rats, were found to alleviate the lipid profiles and lipid metabolizing enzymes. Conclusively, oral treatment of coumarin exhibited in a marked antihyperlipidemic effect against diabetes mellitus.
Le texte complet de cet article est disponible en PDF.Keywords : Coumarin, Diabetes, Lipids
Abbreviations : HDL, HMG-CoA, LDL, LPL, LCAT, VLDL
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Vol 4 - N° 2
P. 171-176 - avril 2014 Retour au numéro
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