Child- and Family-Focused Cognitive-Behavioral Therapy for Pediatric Bipolar Disorder: A Randomized Clinical Trial - 24/10/14
, Sally M. Weinstein, PhD a, Amy T. Peters, MA a, Andrea C. Katz, MA a, David B. Henry, PhD a, b, Rick A. Cruz, MA c, Mani N. Pavuluri, MD, PhD aAbstract |
Objective |
Previous studies have found that family-based psychosocial treatments are effective adjuncts to pharmacotherapy among adults and adolescents with bipolar disorder (BD). The objective of this study was to compare the efficacy of adjunctive child- and family-focused cognitive-behavioral therapy (CFF-CBT) to psychotherapy as usual (control) for mood symptom severity and global functioning in children with BD.
Method |
Sixty-nine youth, aged 7 to 13 years (mean = 9.19, SD = 1.61) with DSM-IV-TR bipolar I, II, or not otherwise specified (NOS) disorder were randomly assigned to CFF-CBT or control groups. Both treatments consisted of 12 weekly sessions followed by 6 monthly booster sessions delivered over a total of 9 months. Independent evaluators assessed participants at baseline, week 4, week 8, week 12 (posttreatment), and week 39 (6-month follow-up).
Results |
Participants in CFF-CBT attended more sessions, were less likely to drop out, and reported greater satisfaction with treatment than controls. CFF-CBT demonstrated efficacy compared to the control treatment in reducing parent-reported mania at posttreatment and depression symptoms at posttreatment and follow-up. Global functioning did not differ at posttreatment but was higher among CFF-CBT participants at follow-up.
Conclusion |
CFF-CBT may be efficacious in reducing acute mood symptoms and improving long-term psychosocial functioning among children with BD.
Le texte complet de cet article est disponible en PDF.Key Words : pediatric bipolar disorder, cognitive-behavioral therapy, family-focused intervention, randomized clinical trial
Plan
| Clinical guidance is available at the end of this article. |
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| This research was supported by the National Institutes of Mental Health (NIMH) K23 grant MH079935 (A.E.W.). |
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| Dr. Henry served as the statistical expert for this research. |
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| Disclosures: Dr. West has received honoraria from the NIH (grant review), Northwestern University (Grand Rounds), and University of Lund (academic talk). Dr. Weinstein has received funding from the American Foundation for Suicide Prevention (AFSP) and honoraria from the University of Lund (academic talk). Dr. Henry has received funding from the National Institute of Justice, National Institute of Drug Abuse, NIMH, Center for Disease Control and Prevention, and the McCormick Foundation. He has received honoraria and consultancies from Rush University, the Center for Alaska Native Health Research, and the University of Virginia Curry School of Education. Dr. Pavuluri has received grant support from the following sources: NIH, NIMH, the National Alliance for Research on Schizophrenia and Depression (NARSAD), the American Foundation for Suicide Prevention, and the Marshall Reynolds Foundation. She is the recipient of the Berger-Colbeth Term Chair in Child Psychiatry and participated in the Otsuka Pharmaceuticals National Advisory Board meeting once. Mr. Cruz has received grant support from the National Institute of Drug Abuse. He has consulted for Mental Health Data Services, Inc. Ms. Peters and Ms. Katz report no biomedical financial interests or potential conflicts of interest. |
Vol 53 - N° 11
P. 1168 - novembre 2014 Retour au numéro
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