The effect of maternal sleep-disordered breathing on the infant’s neurodevelopment - 25/01/15

Doi : 10.1016/j.ajog.2015.01.001

Riva Tauman, MD ^a,^e,^⁎ , Luba Zuk, PhD ^c,^e, Shimrit Uliel-Sibony, MD ^b,^e, Jessica Ascher-Landsberg, MD ^d,^e, Shlomit Katsav, BSc ^a, Mira Farber, BSc ^a, Yakov Sivan, MD ^a,^e, Haim Bassan, MD ^b,^e
^a Sleep Disorders Center, Tel Aviv, Israel
^b Child Neurology and Developmental Unit, Tel Aviv, Israel
^c Department of Physical Therapy, Tel Aviv Medical Center, Tel Aviv, Israel
^d Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv Medical Center, Tel Aviv, Israel
^e Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

^∗Corresponding author: Riva Tauman, MD.

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Abstract

Objective

We sought to examine the effect of maternal sleep-disordered breathing (SDB) on infant general movements (GMs) and neurodevelopment.

Study Design

Pregnant women with uncomplicated full-term pregnancies and their offspring were prospectively recruited from a community and hospital low-risk obstetric surveillance. All participants completed a sleep questionnaire on second trimester and underwent ambulatory sleep evaluation (WatchPAT; Itamar Medical, Caesarea, Israel). They were categorized as SDB (apnea hypopnea index >5) and controls. Infant GMs were assessed in the first 48 hours and at 8-11 and 14-16 weeks of age. At 12 months of age the Infant Developmental Inventory and the Brief Infant Sleep Questionnaire were administered.

Results

In all, 74 women and their full-term infants were studied. Eighteen (24%) women had SDB. Mean birthweight was 3347.1 ± 423.9 g. Median Apgar score at 5 minutes was 10 (range, 8–10). In adjusted comparisons, no differences were found between infants born to mothers with SDB and controls in GM scores in all 3 evaluations. Low social developmental score was detected at 12 months in 64% of infants born to SDB mothers compared to 25% of infants born to controls (adjusted P = .036; odds ratio, 16.7). Infant snoring was reported by 41.7% of mothers with SDB compared to 7.5% of controls (P = .004).

Conclusion

Our preliminary results suggest that maternal SDB during pregnancy has no adverse effect on neonatal and infant neuromotor development but may affect social development at 1 year.

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Key words : fetal outcome, neurodevelopment, pregnancy, sleep-disordered breathing

Plan

Materials and Methods

Maternal and infant data

	This research was supported by grant number 707/12, Israel Science Foundation.
	The authors report no conflict of interest.
	Cite this article as: Tauman R, Zuk L, Uliel-Sibony S, et al. The effect of maternal sleep-disordered breathing on the infant’s neurodevelopment. Am J Obstet Gynecol 2015;212:x.ex-x.ex.