Spatial analysis of advanced-stage ovarian cancer mortality in California - 26/02/15

Doi : 10.1016/j.ajog.2015.01.045

Robert E. Bristow, MD, MBA ^a,^b,^⁎ , Jenny Chang, MPH ^c, Argyrios Ziogas, PhD ^c, Daniel L. Gillen, PhD ^b,^d, Lu Bai, MS ^d, Veronica M. Vieira, DSc ^d,^e
^a Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of California, Irvine, Medical Center, Orange, CA
^b Chao Family Comprehensive Cancer Center, University of California, Irvine, Medical Center, Orange, CA
^c Department of Epidemiology, University of California, Irvine, School of Medicine, Irvine, CA
^d Department of Statistics, University of California, Irvine, School of Medicine, Irvine, CA
^e Program in Public Health, University of California, Irvine, School of Medicine, Irvine, CA

^∗Corresponding author: Robert E. Bristow, MD, MBA.

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Abstract

Objective

We sought to determine the impact of geographic location on advanced-stage ovarian cancer mortality in relation to adherence to National Comprehensive Cancer Network (NCCN) treatment guidelines and hospital case volume.

Study Design

This was a retrospective observational cohort study of patients diagnosed with stage IIIC/IV epithelial ovarian cancer (Jan. 1, 1996, through Dec. 31, 2006) identified from the California Cancer Registry. Generalized additive models were created to assess the effect of spatial distributions of geographic location, demographic characteristics, disease-related variables, adherence to NCCN guidelines, and hospital case volume, with simultaneous smoothing of geographic location and adjustment for confounding variables.

Results

A total of 11,765 patients were identified. Twelve of the 378 hospitals (3.2%) were high-volume hospitals (HVH) (≥20 cases/y) and cared for 2112 patients (17.9%). For all patients, the median distance to an HVH was 22.7 km/14.1 miles and 80% were located within 79.6 km/49.5 miles of an HVH. Overall, 45.4% of patients were treated according to NCCN guidelines. The global test for location revealed that geographic position within the state was significantly correlated with ovarian cancer mortality after adjusting for other variables (P < .001). Distance to receive care ≥32 km/20 miles was protective against mortality (hazard ratio [HR], 0.86; 95% confidence interval [CI], 0.79–0.93), while distance from an HVH ≥80 km/50 miles was associated with an increased risk of death (HR, 1.13; 95% CI, 1.03–1.23). The effects of geographic predictors were attenuated when nonadherence to NCCN guidelines (HR, 1.25; 95% CI, 1.18–1.32) and care at an HVH (HR, 0.87; 95% CI, 0.81–0.93) were introduced into the model.

Conclusion

Geographic location is a significant predictor of advanced-stage ovarian cancer mortality and the effect is primarily related to the likelihood of receiving NCCN guideline adherent care and treatment at an HVH.

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Key words : geographic location, ovarian cancer

Plan

Materials and Methods

Population characteristics

Spatial analysis of advanced-stage ovarian cancer mortality

Comment

	R.E.B. was supported in part by an unrestricted research grant from the Queen of Hearts Foundation. V.M.V. was supported by the Superfund Research Program (National Institute of Environmental Health Sciences2P42ES007381-18). Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under award number P30CA062203.
	The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
	The authors report no conflict of interest.
	Cite this article as: Bristow RE, Chang J, Ziogas A, et al. Spatial analysis of advanced-stage ovarian cancer mortality in California. Am J Obstet Gynecol 2015;212:x.ex-x.ex.