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Archives de pédiatrie
Volume 9, n° 9
pages 913-916 (septembre 2002)
Received : 30 July 2001 ;  accepted : 30 May 2002
Intoxication aiguë par organophosphorés à la suite de l'utilisation d'un insecticide comme shampooing anti-poux
Poisoning by organophosphate insecticides used as a hair-rinse against lice

C.  Paget a * ,  S.  Menard b ,  I.  Wroblewski c ,  J.P.  Gout d ,  V.  Danel b ,  M.  Bost a
aDépartement de pédiatrie, centre hospitalier universitaire de Grenoble, BP 217, 38043 Grenoble cedex 09, France 
bUnité de toxicologie clinique, centre hospitalier universitaire de Grenoble, BP 217, 38043 Grenoble cedex 09, France 
cDépartement de réanimation infantile, centre hospitalier universitaire de Grenoble, BP 217, 38043 Grenoble cedex 09, France 
dService de pédiatrie, centre Hospitalier, BP 208, 38506 Voiron cedex, France 

*Auteur correspondant. 15, rue des Rosiers, 74960 Cran Gevrier
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Observation. - Deux enfants ont été hospitalisés pour intoxication aiguë par organophosphorés à la suite de l'utilisation d'un insecticide comme shampooing anti-poux. Les organophosphorés sont des insecticides à activité anticholinestérasique irréversible. L'accumulation d'acétylcholine explique la clinique. Les acétylcholinestérases globulaires et les pseudocholinestérases plasmatiques, marqueurs de l'intoxication, sont très diminuées. Le traitement spécifique fait appel à l'atropine et si besoin à un antidote, le pralidoxime.

Conclusion. - Des intoxications aiguës par organophosphorés sont possibles du fait d'un usage inapproprié de ces insecticides comme shampooing anti-poux. Une information appropriée des utilisateurs est nécessaire.

Mots clés  : Intoxication aiguë ; Organophosphorés ; Insecticides ; Pesticides.

Abstract

Case report. - Two children were admitted for poisoning by organophosphate pesticides applied as hair rinses against lice. These chemical agents inhibit the acetylcholinesterase enzyme at various sites. The resultant accumulation of the transmitter acetylcholine causes abnormal signs and symptoms. The diagnosis is based on a reduction in the blood cholinesterase activity. The specific treatment comprises the administration of atropine and pralidoxime.

Conclusion. - Accidental poisoning by organophosphate insecticides may occur, due to the misuse of such substances as shampoo against lice. An accurate information for users is necessary.

Mots clés  : Poisoning ; Organophosphate ; Insecticides ; Pesticides ; Child.




© 2002  Éditions scientifiques et médicales Elsevier SAS. All Rights Reserved.

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