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European Psychiatry
Volume 25, n° S1
page 29 (2010)
Doi : 10.1016/S0924-9338(10)70029-8
Accepted Symposia: Epigenetic, Genetic, and Molecular Substrates Underpinning Diagnosis and Treatment of Major Depressive Disorder (MDD)
S24-01 - Neuroticism: an intermediate phenotype for major depression
 

D. Rujescu
Dept. of Psychiatry, University of Munich, Munich, Germany 

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There is strong evidence for a heritability of major depression as shown by family, twin- and adoption studies. Several studies suggest a heritability for unipolar depression between 35 and 75% which is much lower than the heritability of bipolar disorder or schizophrenia. There is no doubt, that major depression is not caused by any single gene but it is a disease with complex genetic features. Furthermore, some subtypes, as early-onset or recurrent depression may have a higher heritability than other forms of depression. Neuroticism as an intermediate phenotype of MDD, which is a trait that reflects a tendency toward negative mood states, and has been linked to internalizing depressive conditions. For these reasons Dan Rujescu will present genome-wide and candidate gene studies, demonstrating a genetic approach for discovering potentially important pathogenic pathways for which clinically powerful (bio)markers may eventually be developed. He will discuss neuroticism as an intermediate phenotype of MDD, which is a trait that reflects a tendency toward negative mood states and has been linked to internalizing depressive conditions.


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