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European Psychiatry
Volume 25, n° 6
pages 361-365 (octobre 2010)
Doi : 10.1016/j.eurpsy.2009.12.005
Received : 31 August 2009 ;  accepted : 14 December 2009
Brain anatomy and imaging
Characteristic brain hypoperfusion by 99mTc-ECD single photon emission computed tomography (SPECT) in patients with the first-episode schizophrenia
 

R. Wake a, ⁎ , T. Miyaoka a, K. Kawakami a, K. Tsuchie a, T. Inagaki a, J. Horiguchi a, Y. Yamamoto b, T. Hayashi b, H. Kitagaki b
a Department of Psychiatry, Shimane University School of Medicine, 89-1, Enyacho, Izumo 693-8501, Japan 
b Department of Radiology, Shimane University School of Medicine Hospital, 89-1, Enyacho, Izumo 693-8501, Japan 

Corresponding author. Tel.: +81 853 20 2263; fax: +81 853 20 2260.
Abstract
Objective

In this study, we evaluated brain perfusion in patients with first-episode medicated schizophrenia using the new analytical method, statistical parametric mapping (SPM) applied to single photon emission computed tomography (SPECT).

Method

We performed SPECT with 99-Tc-ethyl cysteinate dimer (99mTc-ECD) of the brain and magnetic resonance imaging (MRI) in patients with schizophrenia (n =30) and control subjects matched for age and gender (n =37). A voxel-by-voxel group analysis was performed using SPM2 (Z >3.0, P <0.001, uncorrected for multiple comparisons).

Result

In comparison with control subjects, the volumes of the bilateral frontal areas were found to be decreased on MRI. Blood flow was found to be reduced in the bilateral temporal areas in the patients with schizophrenia on SPECT.

Conclusion

In this study, patients with first-episode schizophrenia appeared to have significant bilateral temporal hypoperfusion, although temporal volumes were not significantly decreased in comparison with control subjects. Abnormality of temporal lobe blood flow in schizophrenia may show that functional changes occur earlier than structural changes, and may assist in the diagnosis of schizophrenia.


Keywords : Schizophrenia, Neuroimaging, SPECT


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