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Journal of Neuroradiology
Sous presse. Epreuves corrigées par l'auteur. Disponible en ligne depuis le mercredi 10 août 2011
Doi : 10.1016/j.neurad.2011.06.001
Cerebral blood flow modulation by transcutaneous cranial electrical stimulation with Limoge’s current
Modulation du débit sanguin cérébral par electrostimulation cutanée transcrânienne par les courants de Limoge
 

D. Gense de Beaufort a, ⁎ , M. Sesay b , L. Stinus c , R. Thiebaut d , M. Auriacombe e, f , V. Dousset a
a Service de neuroradiologie, hôpital Pellegrin, place Amélie-Raba-Léon, 33076 Bordeaux cedex, France 
b Service d’anesthésie-réanimation 3, hôpital Pellegrin, place Amélie-Raba-Léon, 33076 Bordeaux cedex, France 
c Directeur de recherche (DR1) CNRS UMR-5541, université de Bordeaux-II, 146, rue Léo-Saignat, 33076 Bordeaux cedex, France 
d Inserm U897, unité de soutien méthodologique à la recherche clinique et épidémiologique du CHU de Bordeaux, université Bordeaux-2, Isped, 146, rue Léo-Saignat, 33076 Bordeaux cedex, France 
e Département et laboratoire de psychiatrie (EA4139 Inserm IFR99), université de Bordeaux-II, 146, rue Léo-Saignat, 33076 Bordeaux cedex, France 
f CHU de Bordeaux, centre hospitalier Charles-Perrens, place Amélie-Raba-Léon, 33076 Bordeaux cedex, France 

Corresponding author. Tel.: +33 5 56 79 56 04; fax: +33 5 56 79 56 39.
Summary
Objectives

Transcutaneous cranial electrical stimulation (TCES) delivers a high-frequency (166kHz) pulsed biphasic balanced current with a pulse repetition frequency of 100Hz with 40% duty cycle through a negative electrode and two positive electrodes over the skull. TCES has a proven ability to potentiate anesthesia and analgesia, although the physiological mechanisms of this effect remain unclear. We hypothesized that the mechanism is a modulation of CBF in the central endogenous opioid system. This study aimed at determining the effects of TCES on CBF to elucidate its physiological mechanism.

Methods

Thirty-six healthy volunteers were randomly assigned to active or placebo TCES, and all assessments were double blind. TCES was performed using the Anesthelec™ device. In the stimulated group, an active cable was used, and in the control group (sham), the cable was inactive. CBF was measured by XeCT™ before and after two hours of TCES.

Results

Globally, CBF was unchanged by TCES. However, locally, TCES induced a significant CBF decrease in the brainstem and thalamus, which are structures involved in pain and anxiety (TCES and control CBF decrease were 18.5 and 11.9mL/100g brain tissue/min, respectively).

Conclusion

TCES can modulate local CBF but it has no effect on overall CBF. [Clinical Trials. gov number: NCT00273663].


Keywords : Cerebral blood flow, Transcutaneous electrical stimulation, Brain stimulation, Xenon CT, Brain mapping analyzer

Abbreviations : TCES, CBF, rCBF, XeCT, PET, fMRI, AMY, HIP, INS, BST, STR, THA, CIN, FRO, RCT, OM, SEM, ICC


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Introduction
Patients and methods  (+)
Statistical analysis
Results  (+)
Discussion
Disclosure of interest


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