D. Gense de Beaufort a, ⁎ , M. Sesay b , L. Stinus c , R. Thiebaut d , M. Auriacombe e, f , V. Dousset a
a Service de neuroradiologie, hôpital Pellegrin, place Amélie-Raba-Léon, 33076 Bordeaux cedex, France
b Service d’anesthésie-réanimation 3, hôpital Pellegrin, place Amélie-Raba-Léon, 33076 Bordeaux cedex, France
c Directeur de recherche (DR1) CNRS UMR-5541, université de Bordeaux-II, 146, rue Léo-Saignat, 33076 Bordeaux cedex, France
d Inserm U897, unité de soutien méthodologique à la recherche clinique et épidémiologique du CHU de Bordeaux, université Bordeaux-2, Isped, 146, rue Léo-Saignat, 33076 Bordeaux cedex, France
e Département et laboratoire de psychiatrie (EA4139 Inserm IFR99), université de Bordeaux-II, 146, rue Léo-Saignat, 33076 Bordeaux cedex, France
f CHU de Bordeaux, centre hospitalier Charles-Perrens, place Amélie-Raba-Léon, 33076 Bordeaux cedex, France
Corresponding author. Tel.: +33 5 56 79 56 04; fax: +33 5 56 79 56 39.
Transcutaneous cranial electrical stimulation (TCES) delivers a high-frequency (166kHz) pulsed biphasic balanced current with a pulse repetition frequency of 100Hz with 40% duty cycle through a negative electrode and two positive electrodes over the skull. TCES has a proven ability to potentiate anesthesia and analgesia, although the physiological mechanisms of this effect remain unclear. We hypothesized that the mechanism is a modulation of CBF in the central endogenous opioid system. This study aimed at determining the effects of TCES on CBF to elucidate its physiological mechanism.
Thirty-six healthy volunteers were randomly assigned to active or placebo TCES, and all assessments were double blind. TCES was performed using the Anesthelec™ device. In the stimulated group, an active cable was used, and in the control group (sham), the cable was inactive. CBF was measured by XeCT™ before and after two hours of TCES.
Globally, CBF was unchanged by TCES. However, locally, TCES induced a significant CBF decrease in the brainstem and thalamus, which are structures involved in pain and anxiety (TCES and control CBF decrease were 18.5 and 11.9mL/100g brain tissue/min, respectively).
TCES can modulate local CBF but it has no effect on overall CBF. [Clinical Trials. gov number: NCT00273663].
Keywords : Cerebral blood flow, Transcutaneous electrical stimulation, Brain stimulation, Xenon CT, Brain mapping analyzer
Abbreviations : TCES, CBF, rCBF, XeCT, PET, fMRI, AMY, HIP, INS, BST, STR, THA, CIN, FRO, RCT, OM, SEM, ICC