Access to the full text of this article requires a subscription.
  • If you are a subscriber, please sign in 'My Account' at the top right of the screen.

  • If you want to subscribe to this journal, see our rates


@@#116300@@

Journal of Neuroradiology
Sous presse. Epreuves corrigées par l'auteur. Disponible en ligne depuis le dimanche 14 août 2011
Doi : 10.1016/j.neurad.2011.07.001
Quantification of cerebral tumour blood flow and permeability with T1-weighted dynamic contrast enhanced MRI: A feasibility study
Quantification de la perfusion et de la perméabilité cérébrale par l’IRM dynamique pondérée T1 avec agent de contraste : étude de faisabilité
 

Martine I. Dujardin a, b, ⁎ , Steven P. Sourbron c, Cristo Chaskis d, e, Dirk Verellen f, Tadeusz Stadnik a, Johan de Mey a, Robert Luypaert a
a Department of Radiology/Befy, UZ Brussel, Laarbeeklaan, 101, 1090 Brussels, Belgium 
b University of Hull in association with Hull York Medical School, centre for MR Investigations, Hull Royal Infirmary, Anlaby Road, Hull HU 3 2 JZ, United Kingdom 
c Division of Medical Physics, University of Leeds, Leeds, United Kingdom 
d Department of Neurosurgery, UZ Brussel, Laarbeeklaan, 101, 1090 Brussels, Belgium 
e CHU de Charleroi, Charleroi, Belgium 
f Department of Radiotherapy, UZ Brussel, Laarbeeklaan, 101, 1090 Brussels, Belgium 

Corresponding author.
Summary
Objectives

Recently, T1-weighted DCE-MRI was proposed as an alternative to T2*-weighted DSC-MRI for the quantification of perfusion and permeability in brain tumors. The aim of the present feasibility study was to explore the clinical potential of the technique in different tumor types using a case-based review of initial results.

Patients and methods

The method for data analysis was adapted from cerebral perfusion CT and applied in this study to a small group of patients with grade IV glioma and other brain tumors. The possible use of the proposed methodology was also explored for characterizing, following-up and planning the therapy of brain tumors.

Results

Parametric maps clearly differentiated tumor from the surrounding brain tissue, and also distinguished areas within the tumor presenting with different characteristics, thereby allowing identification of significant target areas for biopsy and/or treatment. Differences in cerebral blood flow (CBF) and lower extraction fractions (E) were observed in various tumors. Progression from a grade II to grade IV glioma over the course of a year was characterized by an increase in CBF and a decrease in E.

Conclusion

DCE-MRI-based quantitative perfusion and permeability may be helpful for tumor-grade characterization, biopsy guidance, radiotherapy planning, radiotherapy monitoring and clinical follow-up, thereby improving the non-invasive characterization of brain tumors.


Keywords : Brain tumors, Perfusion, Permeability, Quantification


OutlineMasquer le plan
Introduction
Patients and methods  (+)
Results  (+)
Discussion
Conclusion
Disclosure of interest


© 2011  Elsevier Masson SAS. All Rights Reserved.
EM-CONSULTE.COM is registrered at the CNIL, déclaration n° 1286925.
As per the Law relating to information storage and personal integrity, you have the right to oppose (art 26 of that law), access (art 34 of that law) and rectify (art 36 of that law) your personal data. You may thus request that your data, should it be inaccurate, incomplete, unclear, outdated, not be used or stored, be corrected, clarified, updated or deleted.
Personal information regarding our website's visitors, including their identity, is confidential.
The owners of this website hereby guarantee to respect the legal confidentiality conditions, applicable in France, and not to disclose this data to third parties.
Close
Article Outline