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European Psychiatry
Volume 21, n° 1
pages 41-47 (janvier 2006)
Doi : 10.1016/j.eurpsy.2005.12.001
Antipsychotic type and correlates of antipsychotic treatment discontinuation in the outpatient treatment of schizophrenia
 

Josep Maria Haro a, ⁎ , Diego Novick b, Mark Belger c, Peter B. Jones d

SOHO advisory board

a Research and Development Unit, Sant Joan de Déu-Serveis de Salut Mental, Dr. Antoni Pujades 42, 08030, Sant Boi, Barcelona, Spain 
b European Health Outcomes Research, Eli Lilly and Company Limited, Windlesham, Surrey, UK 
c European Commercialization Statistics, Eli Lilly and Company Limited, Windlesham, Surrey, UK 
d University of Cambridge, Addenbrooke's Hospital, Cambridge, UK 

Corresponding author.
Abstract

Antipsychotic medication maintenance and the factors influencing it were analyzed using data from the SOHO study, a large observational study of the outcomes of antipsychotic treatment for schizophrenia in Europe. A total of 7186 adult patients in the outpatient setting who were initiating or changing their antipsychotic medication and who were prescribed only one antipsychotic after the baseline visit were analyzed. Medication maintenance at 12 months varied with the type of antipsychotic prescribed, being highest with clozapine (79.5%) and olanzapine (77.0%), and lowest with quetiapine (51.4%) and amisulpride (58.2%). Multiple logistic regression analysis demonstrated that the type of antipsychotic prescribed at baseline was the most important predictor of medication maintenance. Alcohol dependency, taking mood stabilizers, compulsory admission or arrest in the previous 6 months, greater clinical severity, and changing antipsychotic medication due to lack of effectiveness at baseline predicted a higher frequency of medication discontinuation in the subsequent 12 months. In contrast, medication maintenance was higher among patients who were treatment naïve at baseline, socially active or who had loss of libido at baseline. The findings from this study should be interpreted conservatively because of its non-randomized observational design.


Keywords : Schizophrenia, Antipsychotic agents, Treatment outcome, Medication maintenance


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