Inflammatory profile in unstable angina versus stable angina in patients undergoing percutaneous interventions - 09/09/11
Abstract |
Background Inflammatory markers have been shown to be elevated in acute coronary syndromes. Recently, interleukin-6 was demonstrated to be elevated in unstable angina compared with stable angina. However, the effect of percutaneous coronary interventions on the levels of inflammatory markers is less well known.
Methods and Results In this study, we measured the levels of interleukin-6 and interleukin-1 by using enzyme-linked immunosorbent assays in patients with angina pectoris undergoing coronary interventions and in healthy control subjects. Interleukin-6 was significantly elevated in patients with unstable angina compared with patients with stable angina (P = .01). There were no significant differences between the levels of interleukin-1 in patients with unstable angina versus patients with stable angina and healthy control subjects. Furthermore, at 1-month follow-up after percutaneous coronary interventions, there were no longer any significant differences between the levels of interleukin-6 in patients with unstable angina versus patients with stable angina and healthy control subjects.
Conclusions These data suggest that interleukin-6 levels may correlate with instability of atheromatous plaques and that the decrease of interleukin-6 levels after percutaneous coronary interventions may represent plaque reendothelialization and stabilization. (Am Heart J 1998;136:357-61.)
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From the Division of Cardiology, Department of Medicine, Columbia-Presbyterian Medical Center, and Saint Francis Hospital. |
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Supported by National Heart, Lung, and Blood Institute Physician Scientist Award (K11 HL-02578) (L.E.R.) and the Sol and Margaret Berger Foundation (L.E.R.). |
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Reprint requests: LeRoy E. Rabbani, MD, Division of Cardiology, Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th St., New York, NY 10032. |
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4/1/90408 |
Vol 136 - N° 2
P. 357-361 - août 1998 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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