Role of dopamine in non-depressed patients with a history of suicide attempts - 01/01/01
W. Pitchot * , M. Hansenne, M. Ansseau*Correspondence and reprints
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Résumé |
Several data are available about the implication of the dopaminergic system in the control of inward-directed aggression. Previously, we suggested an involvement of D2-dopaminergic function in the expression of suicidal behavior by demonstrating a smaller growth hormone (GH) response to apomorphine, a dopaminergic agonist, in depressed patients with a history of suicide attempts in comparison to non-attempters. In the present study, in order to test this hypothesis, GH responses to intravenous apomorphine were measured in non-depressed patients with a history of suicide attempts. The study was performed in 17 non-depressed male patients with a score less than 12 on the 17-item HAMD. The patients were subgrouped into suicide attempters (N = 7) and non-attempters (N = 10). Mean GH peak responses to apomorphine differed significantly between suicide attempters and non-attempters: (mean ± SD) for GH peak, 10.4 ± 8.2 ng/mL vs 27.3 ± 13.1 ng/ml, F = 9.0, P = 0.009. In conclusion, dopaminergic disturbances seem to play a role in the biology of inward-directed aggression in non-depressed patients.
Mots clés : depression ; dopamine ; monoamine ; suicide.
Plan
Vol 16 - N° 7
P. 424-427 - novembre 2001 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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