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Journal of Neuroradiology
Sous presse. Epreuves corrigées par l'auteur. Disponible en ligne depuis le mercredi 26 octobre 2011
Doi : 10.1016/j.neurad.2011.09.004
Measures of spinal canal stenosis and relationship to spinal cord structure in patients with cervical spondylosis
Mesures de la sténose du canal rachidien et relations avec la structure du cordon médullaire chez des patients avec cervicarthrose
 

P.G. Lindberg a, b, c, ⁎ , A. Feydy a, b, c, K. Sanchez e, F. Rannou e, M.A. Maier a, b, d
a Centre national de la recherche scientifique (CNRS), unité mixte de recherche (UMR) 8194, centre d’études de la sensorimotricité, 75006 Paris, France 
b Université Paris-Descartes (Paris-5), Sorbonne Paris Cité, 75006 Paris, France 
c Service de radiologie B, faculté de médecine, université Paris-Descartes, CHU Cochin, AP–HP, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France 
d Université Paris-Diderot, Sorbonne Paris Cité, 75205 Paris, France 
e Service de rééducation, faculté de médecine, université Paris-Descartes, CHU Cochin, AP–HP, Sorbonne Paris Cité, 75014 Paris, France 

Corresponding author. Tel.: +33 6 9905 9627; fax: +33 1 4326 6552.
Summary
Objectives

Spinal canal stenosis is often measured on anatomical magnetic resonance imaging (MRI) to estimate the degree of spinal cord compression. This study examined whether two quantitative measures of spinal canal stenosis taken from anatomical MRI are related to spinal cord white-matter integrity in patients with cervical spondylosis measured by diffusion tensor imaging (DTI).

Patients and methods

DTI and T2-weighted MRI of the cervical spinal cord were performed in 15 patients with cervical spondylosis and ten healthy control subjects of similar age. Severity of stenosis was calculated using Pavlov’s ratio and the space-available-for-cord (SAC) technique.

Results

Patients had significantly lower Pavlov’s ratios and SAC (C2–C3, C4–C5 and C6–C7), lower fractional anisotropy (FA; C2–C3 and C4–C5) and higher radial diffusivity (C2–C3, C4–C5 and C6–C7) than the controls. In patients, only Pavlov’s ratio correlated with mean FA (R=0.66, P =0.008). Variations in Pavlov’s ratio and FA also showed a similar pattern across cervical levels.

Conclusion

Pavlov’s ratio is a better predictor of spinal cord integrity than the SAC and, therefore, may be more relevant clinically for the evaluation of stenosis in patients with cervical spondylosis.


Keywords : Spinal cord, MRI, Cervical spondylosis, Spinal stenosis, Pavlov’s ratio


OutlineMasquer le plan
Introduction
Patients and methods  (+)
Results  (+)
Discussion
Conclusion
Disclosure of interest


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