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Journal of Neuroradiology
Sous presse. Epreuves corrigées par l'auteur. Disponible en ligne depuis le vendredi 23 décembre 2011
Doi : 10.1016/j.neurad.2011.11.001
Neuroimaging features and pathology of mixed glioblastoma–AVM complex: A case report
Caractéristiques en neuro-imagerie et anatomopathologie d’une lésion complexe associant un glioblastome (GBM) et une malformation artérioveineuse (MAV)
 

Julie Aucourt a, b, Patrice Jissendi a, b, Olivier Kerdraon a, c, Marc Baroncini a, d, ⁎
a Université Lille-Nord-de-France, 59000 Lille, France 
b Lille University Hospital, Department of Neuroradiology, rue du Pr-E-Laine, 59037 Lille cedex, France 
c Lille University Hospital, Department of Pathology, rue du Pr-E-Laine, 59037 Lille cedex, France 
d Lille University Hospital, Department of Neurosurgery, rue du Pr-E-Laine, 59037 Lille cedex, France 

Corresponding author. Tel.: +33 3 20 44 66 15; fax: +33 3 20 44 66 23.
Summary

This report is of a rare case of glioblastoma coexisting with an arteriovenous malformation in a 65-year-old man. Multimodal magnetic resonance imaging (MRI) performed at 3T revealed a necrotic and cystic lesion in the left hemisphere; morphological and metabolic findings were consistent with an infiltrating high-grade glioma, but the presence of dark vessel-like signals on T2* and susceptibility-weighted imaging (SWI) suggested the coexistence of a vascular malformation. The arteriovenous malformation was confirmed by MR angiography and cerebral angiography. The patient was operated on, and histological examination revealed atypical cells characteristic of glioblastoma multiforme and, in the same area, arteriovenous malformation. The possible role of angiogenic factors in this case is also addressed.


Keywords : Glioblastoma multiforme, Arteriovenous malformation, Neuroimaging, Pro-angiogenic factors


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Introduction
Case report
Discussion
Conclusion
Disclosure of interest


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Start of article
Introduction
Case report
Discussion
Conclusion
Disclosure of interest
References