P-458 - Therapeutically strategies and outcome in mild cognitive impairment - 13/06/12
Résumé |
Introduction |
Mild cognitive impairment(MCI) is considered to be a potential transitional stage between normal cognitive function and dementia.
Objective |
To determine comparatively the outcome of patients treated with different therapies.
Methods |
There were included 193 subjects with MCI, aged over 65. They were evaluated after 6 months, 1 year and 2 years of treatment using Mini Mental State Examination (MMSE) and clock test.
• | Group A -43 patients treated with piracetamum(daily dose:1600mg). |
• | Group B that comprises 44 patients diagnosed with MCI treated with rhodiola rosea, 2 capsules/day. |
• | Group C -41 patients which were treated with antioxidant agents(vitaminE 800ui/day). |
• | Group D -36 subjects treated with piracetamum associated with rhodiola rosea and vitamin E. |
• | Group E -29 patients without treatment. |
Results |
Mean of MMSE score at inclusion was 24,49 (SD=2,1). After 6 months of treatment MMSE score improve in groups treated with 1,35 points in group A, 1,41 for group B, 1,12 points for group C, 1,18 points in group D and in group E we observed an impairment with 0,52 points. In groups A, B, C and D after 1 year of treatment the improvement is with 2,07; 2,03, 2,68 and 3,03 points comparing with the impairment in group E of 1,69 points. Evaluation after 2 years of treatment show a better improvement for group D (3,3 points), followed by group C (2,63 points), group B (2,43 points) and group A (2,23 points) and a greater impairment in group E (2,49 points).
Conclusion |
MCI has a better evolution in group treated with a combined therapy comparing with groups treated with monotherapy and in group E the patients present an impairment of cognitive function.
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Vol 27 - N° S1
P. 1 - 2012 Retour au numéro
Article précédent
- P-457 - Dementia in elderly long term inpatients with serious mental illness
- P. Ntounas, C. Tsopelas, M. Dimitraka, D. Pappas, P. Chatzimanolis, E. Siouti, C. Touloumis, A. Douzenis, L. Lykouras
- P-459 - Music therapy for the treatment of behavioural and psychological symptoms of dementia: a systematic literature review
- C.L. Potter, A. Scott
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