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Biomedicine and Aging Pathology
Volume 2, n° 3
pages 99-103 (juillet 2012)
Doi : 10.1016/j.biomag.2012.07.005
Received : 16 May 2012 ;  accepted : 9 July 2012
Original articles

Effect of Terminalia chebula fruit extract on ethylene glycol induced urolithiasis in rats
 

Anil T. Pawar , Gayatri D. Gaikwad, Kavita S. Metkari, Kiran A. Tijore, Jaydip V. Ghodasara, Bhanudas S. Kuchekar
Department of Pharmacology, MAEER’s Maharashtra Institute of Pharmacy, Paud Road, Kothrud, Pune, Maharashtra 411033, India 

Corresponding author. Tel.: +91 020 30273653; fax: +91 020 25460616.
Abstract
Aim

The present study was undertaken to investigate antiurolithiatic property of aqueous extract of fruit of Terminalia chebula in Wistar albino rats.

Materials and methods

The protective effect of aqueous extract of Terminalia chebula fruit was evaluated at two dose levels (100 and 200mg/kg body weight) using ethylene glycol induced calcium oxalate urolithiasis model in rats.

Results

The results indicate that ethylene glycol treatment decreases calcium level in urine and increased that in the kidney tissue homogenate, which were prevented in animal receiving simultaneous treatment of extract. Extract treatment decreased the elevated levels of oxalate and phosphate in urine as well as kidney tissue homogenate. The extract supplementation also prevented the elevation of serum levels creatinine, uric acid and blood urea nitrogen. Histopathological study revealed that extract reduced histological changes and retained the normal architecture of kidney tissue.

Conclusion

This finding indicates that aqueous extract of Terminalia chebula fruit possessed antiurolithiatic activity.

The full text of this article is available in PDF format.

Keywords : Calcium oxalate, Ethylene glycol, Terminalia chebula , Urolithiasis




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