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Biomedicine and Preventive Nutrition
Volume 3, n° 2
pages 151-157 (avril 2013)
Doi : 10.1016/j.bionut.2012.12.006
Received : 9 November 2012 ;  accepted : 12 December 2012
Immunomodulatory activity of isoflavones isolated from Iris kashmiriana : Effect on T-lymphocyte proliferation and cytokine production in Balb/c mice
 

Nighat Nazir
Department of Chemistry, Islamia College of Science and Commerce, Hawal, Srinagar 190002, J&K, India 

Abstract

This study deals with the evaluation of immunomodulatory action of a new isoflavone isonigricin (1) and first report isoirisolidone (2) isolated from rhizomes of Iris kashmiriana. Flowcytometric method was employed to study their effect on production of T-lymphocytes (CD4+ and CD8+ T-cells) and T-cell cytokines (IL-2, IL-4 and IFN-γ) in a dose-dependant manner. Drugs at doses of 0.025 to 0.8mg/kg per oral dose showed compound 1 to possess immunosuppressant activity on T-cells as well as cytokines, while compound 2 acted as immunostimulator for both cells and cytokines. However, their methylated products viz. 1OMe and 2OMe exhibited stimulatory effect on interleukins under study and suppressive effect on production of T-lymphocytes and IFN-γ. The oral LD50 in mice was observed to be more than 200mg/kg body weight. Such a difference in their activity is the manifestation of the position and nature of substituents present on isoflavonoidal skeleton and demonstrates the potential of these isolates as prospective immunomodulatory agents.

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Keywords : Iris kashmiriana , Iridaceae, Isoflavones, Cytokines, Immunomodulators, Flowcytometry




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