Article

1 Iconography
Access to the text (HTML) Access to the text (HTML)
PDF Access to the PDF text
Advertising


Access to the full text of this article requires a subscription.
  • If you are a subscriber, please sign in 'My Account' at the top right of the screen.

  • If you want to subscribe to this journal, see our rates



Biomedicine and Aging Pathology
Volume 4, n° 1
pages 29-32 (janvier 2014)
Doi : 10.1016/j.biomag.2013.10.005
Received : 30 August 2013 ;  accepted : 2 October 2013
Anticonvulsant activity of Morusin isolated from Morus alba : Modulation of GABA receptor
 

Gaurav Gupta a, , b , Kamal Dua a, Imran Kazmi c, Firoz Anwar c
a School of Pharmacy, International Medical University, Bukit Jalil, 57000 Kuala Lumpur, Malaysia 
b Pacific University, Udaipur, Rajasthan, India 
c Department of Pharmacology, Siddhartha Institute of Pharmacy, Dehra Dun, Uttarakhand, India 

Corresponding author. Tel.: +0169270450.
Abstract
Aim of the study

Epilepsy is a complex neurological disorder affecting 50 million of world's total population. Number of medicinal plants has been used to treat the convulsion. In ancient time Morus alba was used to treat epilepsy and mental illness. In Chinese medicine also M.  alba is used as neuroprotective herbs. The present study was designed to explore the effect of Morusin, a flavonoid glycoside isolated from M.  alba as anticonvulsant activity along with biochemical mechanism.

Materials and methods

Morusin was isolated from M.  alba and acute toxicity study was determined. Anticonvulsant activity of Morusin (5 and 10mg/kg, i.p.) was studied by using isoniazid (INH) and maximal electroshock (MES)-induced convulsion models; diazepam (5mg/kg) and phenytoin (20mg/kg) were used as standards, respectively. Biochemical mechanism was investigated by estimating the GABA level in brain.

Results

The median lethal dose (LD50 ) of Morusin was found up to 20mg/kg. Treatment with Morusin (5 and 10mg/kg) delayed onset of convulsion and tonic hind limb extension along with duration of tonic-clonic convulsions as well as it significantly reduced mortality in INH and MES-induced convulsion. Rats treated with Morusin (5 and 10mg/kg) significantly increased level of brain GABA at both doses.

Conclusion

The findings of current study provide pharmacological credibility to anticonvulsant activity of Morusin. The protection against the convulsions and restoration of GABA level give a suggestion to its probable mechanism of action.

The full text of this article is available in PDF format.

Keywords : Anticonvulsant activity, Morusin, Isoniazid, Maximum electroshock, GABA




© 2013  Elsevier Masson SAS. All Rights Reserved.
EM-CONSULTE.COM is registrered at the CNIL, déclaration n° 1286925.
As per the Law relating to information storage and personal integrity, you have the right to oppose (art 26 of that law), access (art 34 of that law) and rectify (art 36 of that law) your personal data. You may thus request that your data, should it be inaccurate, incomplete, unclear, outdated, not be used or stored, be corrected, clarified, updated or deleted.
Personal information regarding our website's visitors, including their identity, is confidential.
The owners of this website hereby guarantee to respect the legal confidentiality conditions, applicable in France, and not to disclose this data to third parties.
Close
Article Outline