Preterm birth, infant weight gain, and childhood asthma risk: A meta-analysis of 147,000 European children - 27/04/14
Doi : 10.1016/j.jaci.2013.12.1082
Agnes M.M. Sonnenschein-van der Voort, PhD a, b, c, Lidia R. Arends, PhD d, e, f, Johan C. de Jongste, MD, PhD c, Isabella Annesi-Maesano, MD, PhD g, h, S. Hasan Arshad, DM i, Henrique Barros, MD, PhD j, Mikel Basterrechea, MD k, l, Hans Bisgaard, MD, DMSci m, n, Leda Chatzi, MD, PhD o, Eva Corpeleijn, PhD p, Sofia Correia, PharmD, MSc j, Leone C. Craig, MD, PhD q, Graham Devereux, MD, PhD q, Cristian Dogaru, MD, PhD r, Miroslav Dostal, MD, DSc s, Karel Duchen, MD t, Merete Eggesbø, MD, PhD u, C. Kors van der Ent, MD, PhD v, Maria P. Fantini, MD w, Francesco Forastiere, MD, PhD x, Urs Frey, MD, PhD y, Ulrike Gehring, PhD z, Davide Gori, MD w, Anne C. van der Gugten, MD, PhD v, Wojciech Hanke, MD, PhD aa, A. John Henderson, MD, PhD bb, Barbara Heude, PhD cc, dd, Carmen Iñiguez, PhD l, ee, ff, Hazel M. Inskip, MSc, PhD gg, Thomas Keil, MD, MScPH hh, ii, Cecily C. Kelleher, MD, MPH jj, Manolis Kogevinas, MD, PhD kk, Eskil Kreiner-Møller, MD m, n, Claudia E. Kuehni, MD, PhD r, Leanne K. Küpers, MSc p, Kinga Lancz, PhD ll, Pernille S. Larsen, MSc mm, Susanne Lau, MD, PhD nn, Johnny Ludvigsson, MD, PhD t, Monique Mommers, PhD oo, Anne-Marie Nybo Andersen, MD, PhD mm, Lubica Palkovicova, MD, PhD ll, Katharine C. Pike, MD, PhD pp, Costanza Pizzi, MSc qq, Kinga Polanska, PhD aa, Daniela Porta, MSc x, Lorenzo Richiardi, MD, PhD qq, Graham Roberts, DM i, Anne Schmidt, MD rr, Radim J. Sram, MD, DSc s, Jordi Sunyer, MD, PhD l, ss, tt, uu, Carel Thijs, MD, PhD oo, Maties Torrent, MD, PhD vv, Karien Viljoen, MBChB, MSc jj, Alet H. Wijga, PhD ww, Martine Vrijheid, PhD l, ss, tt, Vincent W.V. Jaddoe, MD, PhD a, b, xx, Liesbeth Duijts, MD, PhD b, c, yy, ⁎ 
a Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
b Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
c Department of Paediatrics, Division of Respiratory Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
d Department of Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
xx Department of Paediatrics, Erasmus Medical Center, Rotterdam, The Netherlands
yy Department of Paediatrics, Division of Neonatology, Erasmus Medical Center, Rotterdam, The Netherlands
e Institute of Pedagogical Sciences, Erasmus University Rotterdam, Rotterdam, The Netherlands
f Institute of Psychology, Erasmus University Rotterdam, Rotterdam, The Netherlands
g EPAR, UMR-S 707 INSERM Paris, Paris, France
h EPAR, UMR-S 707, Université Pierre et Marie Curie Paris 06, Paris, France
i David Hide Asthma and Allergy Research Centre, St Mary's Hospital, Newport, Isle of Wight, United Kingdom
j Department of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, Porto, Portugal
k Public Health Division of Gipuzkoa, Gipuzkoa, Spain
l Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Barcelona, Spain
m Copenhagen Prospective Studies on Asthma in Childhood (COPSAC), Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
mm Section of Social Medicine, Department of Public Health, University of Copenhagen, Copenhagen, Denmark
n Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Denmark
o Department of Social Medicine, School of Medicine, University of Crete, Crete, Greece
p Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
q Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom
r Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
s Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic
t Division of Pediatrics, Department of Clinical and Experimental Medicine, Linköping University, and Pediatric Clinic, County Council of Östergötland County Council, Linköping, Sweden
u Department of Genes and Environment, Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway
v Department of Paediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
w Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy
x Department of Epidemiology, Lazio Regional Health Service, Rome, Italy
y University Children's Hospital Basel (UKBB), University of Basel, Basel, Switzerland
z Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
aa Nofer Institute of Occupational Medicine, Department of Environmental Epidemiology, Lodz, Poland
bb School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
cc INSERM, Center for Research in Epidemiology and Population Health, U1018, Lifelong Epidemiology Of Obesity, Diabetes, and Renal Disease Team, Villejuif, France
dd University Paris-Sud, Villejuif, France
ee Center for Public Health Research (CSISP), University of Valencia, Valencia, Spain
ff Faculty of nursery and chiropody, University of Valencia, Valencia, Spain
gg MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
hh Institute of Social Medicine, Epidemiology and Health Economics, Charité University Medical Center, Berlin, Germany
ii Institute for Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany
jj School of Public Health, Physiotherapy and Population Science, University College Dublin, Dublin, Ireland
kk National School of Public Health, Athens, Greece
ll Department of Environmental Medicine, Faculty of Public Health, Slovak Medical University, Bratislava, Slovakia
nn Department of Paediatric Pneumology and Immunology, Charité University Medical Centre, Berlin, Germany
oo Department of Epidemiology, CAPHRI School for Public Health and Primary Care, Maastricht University, Maastricht, The Netherlands
pp Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
qq Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin, Turin, Italy
rr Division of Respiratory Medicine, Department of Pediatrics, Inselspital, University of Bern, Bern, Switzerland
ss Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain
tt Department of Experimental and Health Sciences, Pompeu Fabra University, Barcelona, Spain
uu Institut Municipal d’Investigació Mèdica (IMIM)–Hospital del Mar, Barcelona, Spain
vv IB-SALUT, Area de Salut de Menorca, Balearic Islands, Spain
ww Centre for Prevention and Health Services Research, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands
∗Corresponding author: Liesbeth Duijts, MD, PhD, Erasmus Medical Center–Sophia Children's Hospital, Sp-3435, PO Box 2060, 3000 CB Rotterdam, The Netherlands.
Abstract |
Background |
Preterm birth, low birth weight, and infant catch-up growth seem associated with an increased risk of respiratory diseases in later life, but individual studies showed conflicting results.
Objectives |
We performed an individual participant data meta-analysis for 147,252 children of 31 birth cohort studies to determine the associations of birth and infant growth characteristics with the risks of preschool wheezing (1-4 years) and school-age asthma (5-10 years).
Methods |
First, we performed an adjusted 1-stage random-effect meta-analysis to assess the combined associations of gestational age, birth weight, and infant weight gain with childhood asthma. Second, we performed an adjusted 2-stage random-effect meta-analysis to assess the associations of preterm birth (gestational age <37 weeks) and low birth weight (<2500 g) with childhood asthma outcomes.
Results |
Younger gestational age at birth and higher infant weight gain were independently associated with higher risks of preschool wheezing and school-age asthma (P < .05). The inverse associations of birth weight with childhood asthma were explained by gestational age at birth. Compared with term-born children with normal infant weight gain, we observed the highest risks of school-age asthma in children born preterm with high infant weight gain (odds ratio [OR], 4.47; 95% CI, 2.58-7.76). Preterm birth was positively associated with an increased risk of preschool wheezing (pooled odds ratio [pOR], 1.34; 95% CI, 1.25-1.43) and school-age asthma (pOR, 1.40; 95% CI, 1.18-1.67) independent of birth weight. Weaker effect estimates were observed for the associations of low birth weight adjusted for gestational age at birth with preschool wheezing (pOR, 1.10; 95% CI, 1.00-1.21) and school-age asthma (pOR, 1.13; 95% CI, 1.01-1.27).
Conclusion |
Younger gestational age at birth and higher infant weight gain were associated with childhood asthma outcomes. The associations of lower birth weight with childhood asthma were largely explained by gestational age at birth.
Le texte complet de cet article est disponible en PDF.Key words : Gestational age, low birth weight, infant growth, wheezing, asthma, children, cohort studies, epidemiology
Abbreviations used : BMI, ISAAC, OR, pOR, SDS
Plan
| Supported by the European Community's Seventh Framework Programme FP7/2007-2013, project CHICOS. The research leading to these results has received funding from the European Respiratory Society and the European Community's Seventh Framework Programme FP7/2007-2013–Marie Curie Actions under grant agreement RESPIRE, PCOFUND-GA-2008-229571. |
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| Disclosure of potential conflict of interest: I. Annesi-Maesano has received one or more grants from or has one or more grants pending with UE. S. H. Arshad has been supported by one or more grants from the National Institute of Health and Asthma UK and has received one or more payments for lecturing from or is on the speakers' bureau for Thermo Fisher and GlaxoSmithKline. H. Bisgaard has been supported by one or more grants from the Danish State Budget and the Lundbeck Foundation, has consultancy arrangements with Chiesi Pharmaceuticals, and has received one or more grants from or has one or more grants pending with the Danish Strategic Research Council, the Capital Region of Denmark, the Oticon Foundation, the European Research Council, and the Danish Council for Independent Research, Medical Sciences. C. Dogaru and C. E. Kuehni are employed by the University of Bern. M. Eggesbø has been supported by one or more grants from and has received support for travel from Chicos. A. J. Henderson has been supported by one or more grants from the Wellcome Trust and the Medical Research Council. H. M. Inskip has been supported by one or more grants from the UK Medical Research Council and many funding bodies and is a Board member for the UK Medical Research Council. T. Keil has received one or more grants from or has one or more grants pending with the European Commission. K. Lancz and L. Palkovicova have been supported by one or more grants from the NIH (NCI and Fogarty), the European Union, and the Slovak Ministry of Health. S. Lau has been supported by one or more grants from the German Research Foundation DFG, is a member of the Merck Drug monitoring committee, has consultancy arrangements with Allergopharma (Reinbek, Germany), has received one or more grants from or has one or more grants pending with Symbiopharm (Herborn, Germany), and has received one or more payments for lecturing from or is on the speakers' bureau for Symbiopharm, GlaxoSmithKline, CSL Behring. M. Mommers has been supported by one or more grants from the Netherlands Asthma Foundation and has received support for travel from the European Community Seventh Framework Programme. K. C. Pike has been supported by one or more grants from FSA BLF and has received various travel grants and bursaries, most recently from the European Respiratory Society. G. Roberts has been supported by one or more grants from the NIH and BMA. A. Schmidt has been supported by one or more grants from the Swiss National Science Foundation. C. Thijs has been supported by one or more grants from the Netherlands Asthma Foundation and has received support for travel from European Community's Seventh Framework Programme. M. Vrijheid has been supported by one or more grants from and has received support for travel from the European Community's Seventh Framework Programme FP7/2007-2013 (Project CHICOS). L. Duijts has received research support from the European Community's Seventh Framework Programme FP7/2007-2013 (Project CHICOS) and is the recipient of a European Respiratory Society/Marie Curie Joint Research Fellowship (no. MC 1226-2009). The rest of the authors declare that they have no relevant conflicts of interest. |
© 2014
American Academy of Allergy, Asthma & Immunology. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 133 - N° 5
P. 1317-1329 - mai 2014 Retour au numéro
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