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Annales de Dermatologie et de Vénéréologie
Volume 142, n° S1
pages 13-17 (janvier 2015)
Doi : 10.1016/S0151-9638(15)30002-8
Plus il y a de bactéries différentes, moins il y a d’inflammation : la révolution microbiotique
Diversity of cutaneous bacteria decreases inflammation
 

F. Hacard 1, 2, 3, A. Nosbaum 1, 2, 3, 4, V.-A. Huynh 1, J.-F. Nicolas 1, 2, 3, F. Bérard 1, 2, 3,
1 Service immunologie clinique et allergologie, CH Lyon-Sud, 69495 Pierre-Bénite Cedex, France 
2 Inserm U1111-CIRI 
3 Université Claude-Bernard-Lyon I 
4 Department of Dermatology, University of California, San Francisco CA 94143-0511, United States 

*Auteur correspondant.
Résumé

Notre microbiote est l’ensemble des micro-organismes, saprophytes et pathogènes, qui colonisent notre corps. Les récents progrès des techniques d’analyse métagénomiques ont élargi notre connaissance du microbiote et transformé en profondeur notre vision des relations qu’il entretient avec le système immunitaire. La flore saprophyte apparaît comme essentielle au développement harmonieux du système immunitaire, et la diversité du microbiote est corrélée avec le bon niveau de santé des individus. Ces découvertes ouvrent de nouvelles voies conceptuelles et thérapeutiques dans les maladies inflammatoires chroniques.

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Summary

Human microbiota includes all microorganisms, saprophytes and pathogens that colonize our bodies. Recent advances in metagenomic analysis techniques have expanded our knowledge of the microbiota and fundamentally changed our view of its relationships with the immune system. The commensal flora appears to be essential to the development of the immune system, and the diversity of the microbiota is correlated with good health status of individuals. These findings open up new conceptual and therapeutic approaches in chronic inflammatory diseases.

The full text of this article is available in PDF format.

Mots-clés : Microbiome, Peau, Système immunitaire, Inflammation

Keywords : Microbiome, Skin, Immune system, Inflammation




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