History of diabetes and risk of suicide and accidental death in Japan: The Japan Public Health Centre-based Prospective Study, 1990–2012 - 19/01/16

Doi : 10.1016/j.diabet.2015.11.008

T. Yamauchi ^a, M. Inagaki ^b,^⁎ , N. Yonemoto ^c, M. Iwasaki ^d, T. Akechi ^e, N. Sawada ^d, H. Iso ^f, M. Noda ^g, S. Tsugane ^d
on behalf of the
JPHC Study Group
^a Centre for Suicide Prevention, National Institute of Mental Health, National Centre of Neurology and Psychiatry, Tokyo, Japan
^b Department of Neuropsychiatry, Okayama University Hospital, Shikata-cho, Kita-ku, Okayama 700-8558, Japan
^c Department of Neuropsychopharmacology, National Institute of Mental Health, National Centre of Neurology and Psychiatry, Tokyo, Japan
^d Epidemiology and Prevention Group, Research Centre for Cancer Prevention and Screening, National Cancer Centre, Tokyo, Japan
^e Department of Psychiatry and Cognitive-Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan
^f Public Health Graduate School of Medicine, Osaka University, Osaka, Japan
^g Department of Diabetes Research, National Centre for Global Health and Medicine, Tokyo, Japan

^⁎Corresponding author. Tel.: +81 86 235 7242; fax: +81 86 235 7246.

En prensa. Pruebas corregidas por el autor. Disponible en línea desde el Tuesday 19 January 2016
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Abstract

Aim

This study looked at whether a history of diabetes mellitus (DM) is associated with a higher risk of externally caused death (by suicide and accident), using data for a large population-based prospective cohort from an Asian population.

Methods

Data collected between 1990 and 2012 from the Japan Public Health Centre-based Prospective Study were analyzed, and Poisson regression models were used to calculate adjusted risk ratios (RR) for external causes of death.

Results

The population-based cohort comprised 105,408 Japanese residents (49,484 men and 55,924 women; mean age: 51.2 [SD 7.9] years). At baseline, 3250 (6.6%) men and 1648 (3.0%) women had a history of DM. During the follow-up period, 113 external deaths (41 suicides and 72 accidents) were noted among those with a history of DM, with 1304 external deaths (577 suicides and 727 accidents) among those without such a history. A higher risk of external death (men, RR: 1.4, 95% CI: 1.2–1.8; women, RR: 1.6, 95% CI: 1.01–2.4) was observed in those with a history of DM. Also, among those aged 40–49 years (RR: 1.9, 95% CI: 1.3–2.7) and 50–59 years (RR: 1.4, 95% CI: 1.05–1.9) at baseline, the risk of external death was significantly higher in those with a history of DM.

Conclusion

Compared with people with no history of DM, those with such a history had a significantly greater risk of externally caused death (particularly accidental deaths) in both genders and in those aged≤59 years at baseline.

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Keywords : Accidents, Asian population, Cohort studies, Diabetes mellitus, Prospective studies, Suicide