Influence of maternal obesity on the multi-omics profiles of the maternal body, gestational tissue, and offspring - 03/06/22
Abstract |
Epidemiological studies show that obesity during pregnancy affects more than half of the pregnancies in the developed countries and is associated with obstetric problems and poor outcomes. Obesity tends to increase the incidence of complications. Furthermore, the resulting offspring are also adversely affected. However, the molecular mechanisms of obesity leading to poor pregnancy outcomes remain unclear. Omics methods are used for genetic diagnosis and marker discovery. The aim of this review was to summarize the maternal and fetal pathophysiological alterations induced by gestational obesity,identified using multi-omics detection techniques, and to generalize the biological functions and potential mechanisms of the differentially expressed molecules.
El texto completo de este artículo está disponible en PDF.Graphical Abstract |
Highlights |
• | Maternal obesity increases the risk of poor pregnancy outcomes. |
• | Molecular mechanisms of its deleterious effects remain unknown. |
• | Results of omics analyses can help elucidate the underlying mechanisms. |
• | The review summarizes the related omics data and discusses the potential mechanisms. |
Keywords : Maternal obesity, Offspring, Epigenetics, Transcriptomics, Proteomics, Metabolomics
Abbreviations : BMI, GWG, GDM, HFD, CD, DMR, COBRA, BS, BSAS, EWAS, RRBS, PAA, WAT, PACE, SAGE, PBMCs, PPAR, NAFLD, GSEA, hA-MSCs, ROS, MBD, TIGAR
Esquema
Vol 151
Artículo 113103- juillet 2022 Regresar al númeroBienvenido a EM-consulte, la referencia de los profesionales de la salud.
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