Mechanistic and therapeutic perspectives of baicalin and baicalein on pulmonary hypertension: A comprehensive review - 03/06/22
Abstract |
Pulmonary hypertension (PH) is a chronic and fatal disease, for which new therapeutic drugs and approaches are needed urgently. Baicalein and baicalin, the active compounds of the traditional Chinese medicine, Scutellaria baicalensis Georgi, exhibit a wide range of pharmacological activities. Numerous studies involving in vitro and in vivo models of PH have revealed that the treatment with baicalin and baicalein may be effective. This review summarizes the potential mechanisms driving the beneficial effects of baicalin and baicalein treatment on PH, including anti-inflammatory response, inhibition of pulmonary smooth muscle cell proliferation and endothelial-to-mesenchymal transformation, stabilization of the extracellular matrix, and mitigation of oxidative stress. The pharmacokinetics of these compounds have also been reviewed. The therapeutic potential of baicalin and baicalein warrants their continued study as natural treatments for PH.
El texto completo de este artículo está disponible en PDF.Graphical Abstract |
Highlights |
• | The pathogenesis of PH is briefly reviewed from a therapeutic perspective. |
• | The paper summed up the protective effects of baicalein and baicalin on PH in vivo and vitro. |
• | This paper clarified the underlying mechanism of baicalein and baicalin against PH. |
Abbreviations : ADAMTS-1, AKT, BMPR1, BMPR2, BMPs, [Ca2+]i, ECM, EndMT, eNOS, ERK1/2, ET-1, ETAR, GSH-Px, GSK-3, HIF-1, HMGB1, HO-1, HPAH, HPV, IL-1β, IL-6, iNOS, IPAH, MAPK, MCT, MDA, MMP-9, NF-κB, PAECs, PAP, PASMCs, PDGF, PH, PI3K, PIP2, PKC, PPARγ, RhoA, ROCK, ROS, RTK, SOD, TGFβ, TGF-β1, TNF-α, TRPC1, T-SOD, UGT, VSMCs, α-SMA
Keywords : Pulmonary hypertension, Baicalein, Baicalin, Pulmonary artery smooth muscle cells, Pulmonary vascular remodeling, Thrombosis
Esquema
Vol 151
Artículo 113191- juillet 2022 Regresar al númeroBienvenido a EM-consulte, la referencia de los profesionales de la salud.
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