Exposure to environmental risk factors and Congenital Heart Disease: ARTEMIS results - 14/08/18
: Cardiologist, Guyguy Manangama 2, Raphaëlle Teysseire 2, Pierre-Emmanuel Seguela 1 : Cardiologist, Jean-Benoît Thambo 1 : Cardiologist, Fleur Delva 2, 3 : EpidemiologistBienvenue sur EM-consulte, la référence des professionnels de santé.
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Résumé |
Introduction |
Congenital heart defects (CHD) are the most common congenital malformations, with a prevalence of nearly 8 per 1000 live births [1]. Less than 20% of these abnormalities can be attributed to a chromosomal or monogenic anomaly, but in the majority of cases, the cause remains unknown [2]. Some recent studies have identified environmental exposures as possible risk factors for the occurrence of CHD [3, 4].
A critical period during which a woman or a man exposed to an agent is most at risk of congenital malformation in their fetus is now recognized [5, 6]. The ARTEMIS Center, at the Bordeaux University Hospital, is dedicated to the evaluation of environmental exposures in patients with fertility disorders, pregnancy pathologies and congenital malformations.
Objectives |
We aimed to present the prevalence of exposure to reproductive risk factors at the time of critical developmental period in patients managed at the ARTEMIS Center for the presence of a cardiac malformation in their child or fetus.
Results |
Environmental exposures assessment of 45 mothers and 42 spouses were realized (from 2017 to February 2018).
Regarding occupational exposures during the periconceptional period (3 months before, 3 months after the conception) some potential factors were identified: physical strain (9 mothers, 20.9%), drugs (4 mothers, 9.3%, and 3 spouses, 7.1%), organic solvants (3 mothers, 7.0%), pesticides (3 mothers, 7.0%, and 7 spouses, 16.7%), polycyliv aromatimatic hydrocarbons (4 spouses).
Regarding non-occupational exposures, cleaning and maintenance products (12 mothers, 26.7% and 12 spouses, 28.5%), pesticides (8 mothers, 17.8% and 8 spouses, 19.0%), the DIY products (3 mothers, 6.7 and 3 spouses, 7.1%) were identified as well (Table 1).
Conclusion |
Environmental exposures with potential malformative risk have been identified, and prevention measures proposed. Further large studies evaluating the imputability of these exposures on the occurrence of CHD are necessary.
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Vol 10 - N° 3-4
P. 283-284 - septembre 2018 Retour au numéro
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