Pemoline Effects on Children with ADHD: A Time-Response by Dose-Response Analysis on Classroom Measures - 10/09/19

Doi : 10.1097/00004583-199511000-00018

WILLIAM E. PELHAM, Ph.D. ^⁎, JAMES M. SWANSON, Ph.D., MARY BENDER FURMAN, M.A., HEIDI SCHWINDT, B.S.

Dr. Pelham is Professor of Psychiatry and Psychology, University of Pittsburgh, and Director, Attention Deficit Disorder Program, Western Psychiatric Institute and Clinic, Pittsburgh. Dr. Swanson is Professor of Pediatrics and Psychiatry and Director, Child Development Center, University of California, Irvine. Ms. Furman is a therapist at the University of California, Irvine. Ms. Wilson is a Research Assistant, Hospital for Sick Children, Toronto. Ms. Schwindt is a Research Associate, Attention Deficit Disorder Program, University of Pittsburgh

^* Reprint requests to Dr. Pelham, Western Psychiatric Institute and Clinic, 3811 O’Hara Street, Pittsburgh, PA 15213

ABSTRACT

Objective

To evaluate the dose-response by time-response characteristics of pemoline (Cylert®) on dependent measures of behavior and academic performance in a laboratory classroom.

Method

After a 2-week baseline, a double-blind crossover design was used to compare placebo, 18.75 mg, 37.5 mg, 75 mg, and 112.5 mg of pemoline, q.a.m., with each dose administered for 1 week. Medication was given at 9:00 A.M., and performance was measured beginning immediately and beginning 2, 4, and 6 hours after ingestion. The dependent measures included number of math problems completed correctly, teacher-recorded rates of on-task behavior and noncompliance, and teacher ratings on an Abbreviated Conners Teacher Rating Scale.

Results

There were linear effects of medication, with pemoline doses greater than 18.75 mg having an effect beginning 2 hours after ingestion and lasting through the seventh hour after ingestion.

Conclusion

Results are contrasted with widespread misbeliefs regarding pemoline’s time course and efficacy.

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Key Words : pemoline, attention deficit disorder, children, treatment

The authors thank the Hospital for Sick Children, Toronto, Research Institute and Abbott Laboratories, Canada, for their support during this study, and Abbott Laboratories, U.S.A., for support of manuscript preparation. The first author was supported in part by grants AA06267, DA05605, MH40567, MH45576, and MH48157 during the writing of this paper.

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Vol 34 - N° 11

P. 1504-1513 - novembre 1995 Retour au numéro

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Pemoline Effects on Children with ADHD: A Time-Response by Dose-Response Analysis on Classroom Measures - 10/09/19

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