The incidence of hyperprolactinemia in women peaks during the 3rd–4th decade and then greatly decreases after the menopause. It has been linked to secondary osteoporosis, weight gain and insulin resistance, which can be ameliorated following medical treatment. Although relatively rare, prolactinomas can be observed in post-menopausal women.

Here, we report the case of a 57-year-old female with a history of cervical pain treated by neuroleptic, who presented with secondary amenorrhea and galactorrhea for 2 years, persisting despite the withdrawal of medication. On examination, her body mass index was 32 kg/m², her blood pressure was 130/80 mmHg without goiter or hyperandrogenic signs. Her prolactin level was 2735 μUI/L (N=130-500), TSH was 0,88 μUI/ml, and FSH=15,1 mUI/ml, LH=4,1 mUI/ml. The MRI showed an adenoma of 8 mm. Her bone mass density showed a low bone strength. She was treated by dopamine agonist with a favorable issue.

This observation highlights the importance of considering the diagnosis of hyperprolactinemia due to pituitary adenoma mainly in premenopausal women; Symptoms can be confused with those of menopause responsible for a diagnosis delay and Medical treatment should be discussed based on osteoporosis and neoplasic risks.