Pathophysiology of pyoderma gangrenosum (PG): An updated review - 14/09/15
Abstract |
Pyoderma gangrenosum is a challenging skin condition to identify and treat because of its multifactorial pathogenesis. It is a rare cutaneous manifestation diagnosed clinically by exclusion of infection, neoplasia, thrombophilia, and other inflammatory conditions. Pathogenetic and treatment studies are scarce. Abnormalities in the function of inflammatory cytokines, the immune system, and neutrophils combined with specific genetic mutations predispose patients to develop this complex disease process. Early recognition of patients at risk for pyoderma gangrenosum, the necessity to improve its early diagnosis, and the future outlook of targeted and personalized therapies relies on the improved comprehension of the complex pathogenesis of pyoderma gangrenosum.
Le texte complet de cet article est disponible en PDF.Key words : cytokines, genetics, inflammation, neutrophilic dermatoses, pathogenesis, pyoderma gangrenosum
Abbreviations used : G-CSF, GM-CSF, IBD, IL, MMP, PG, PSTPIP
Plan
Funding sources: None. |
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Conflicts of interest: None declared. |
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Reprints not available from the authors. |
Vol 73 - N° 4
P. 691-698 - octobre 2015 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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