Anthropometrics indices of obesity, and all-cause and cardiovascular disease-related mortality, in an Asian cohort with type 2 diabetes mellitus - 15/09/15
Abstract |
Aim |
The study investigated the relationship of general (body mass index [BMI]) and central (waist circumference [WC]; waist–hip ratio [WHipR]; waist–height ratio [WHeightR]) adiposity with all-cause and cardiovascular disease (CVD)-related mortality in an Asian population with diabetes.
Methods |
A total of 13,278 participants with type 2 diabetes mellitus (T2DM) recruited from public-sector primary-care and specialist outpatients clinics in Singapore were followed-up for a median duration of 2.9 years, during which time there were 524 deaths. Cox proportional-hazards regression and competing-risk models were used to obtain hazard ratios (HRs) for anthropometric variables of all-cause and CVD-related mortality.
Results |
After adjusting for BMI, the highest quintiles of WC, WHipR and WHeightR were all positively associated with mortality compared with the lowest quintiles, with WHeightR exhibiting the largest effect sizes [all-cause mortality HR: 2.13, 95% confidence interval (CI): 1.33–3.42; CVD-related mortality HR: 3.42, 95% CI: 1.62–7.19]. Being overweight but not obese (BMI:≥23.0 but<27.5kg/m2) was associated with a decreased risk of CVD-related mortality in those aged≥65 years (HR: 0.47, 95% CI: 0.29–0.75), but not in those aged<65 years (HR: 1.11, 95% CI: 0.49–2.50).
Conclusion |
Overweight, but not obesity, was associated with a reduction in risk of mortality. This was seen in T2DM patients aged≥65 years, but not in those younger than this. At the same BMI, having higher central-obesity indices such as WC, WHipR and WHeightR also increased the risk of mortality.
Le texte complet de cet article est disponible en PDF.Keywords : Short-term mortality, Diabetes mellitus, Obesity, Central obesity, Anthropometric indices
Plan
Vol 41 - N° 4
P. 291-300 - septembre 2015 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.