Adult neurogenesis and brain remodelling after brain injury: From bench to bedside? - 16/09/15
, Catherine Heurteaux b , Carole Ichai a, 1 Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 7 |
| Iconographies | 3 |
| Vidéos | 0 |
| Autres | 0 |
Abstract |
Objective |
Brain trauma and stroke cause important disabilities. The mechanisms involved are now well described, but all therapeutics developed thus far for neuro-protection are currently unsuccessful at improving neurologic prognosis. The recently studied neuro-restorative time following brain injury may point towards a promising therapeutic approach. The purpose of this paper is to explain the mechanisms of this revolutionary concept, give an overview of related knowledge and discuss its transfer into clinical practice.
Data sources and synthesis |
An overview of the neurogenesis concept using MEDLINE, EMBASE and CENTRAL databases was carried out in May 2014. The clinicaltrials.gov registry was used to search for ongoing clinical trials in this domain.
Conclusion |
The concept of brain remodelling upset fundamental ideas concerning the neurologic system and opened new fields of research. Therapies currently under evaluation hold promising results and could have a real prognostic impact in future years, but the translation of these therapies from the laboratory to the clinic is still far from completion.
Le texte complet de cet article est disponible en PDF.Keywords : Neurogenesis, Vasculogenesis, Brain injury, Brain trauma, Stroke, Neuro-restorative treatment
Plan
Vol 34 - N° 4
P. 239-245 - août 2015 Retour au numéro
Article précédent
- Neuron specific enolase and Glasgow motor score remain useful tools for assessing neurological prognosis after out-of-hospital cardiac arrest treated with therapeutic hypothermia
- Claire Roger, Ludovic Palmier, Benjamin Louart, Nicolas Molinari, Pierre-Geraud Claret, Jean-Emmanuel de la Coussaye, Jean-Yves Lefrant, Laurent Muller
- Anaphylactic reaction and cardiac arrest due to gadobenate dimeglumine
- Marie Virtos, Stéphanie Ruiz, Fatima-Zohra Mokrane, Hervé Rousseau, Bernard Georges, Olivier Fourcade, Jean-Marie Conil
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?