Survival in relation to hospital type after resection or sorafenib treatment for hepatocellular carcinoma in The Netherlands - 14/12/15
, Rob A. de Man e, 2Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 11 |
| Iconographies | 4 |
| Vidéos | 0 |
| Autres | 0 |
Summary |
Background and objective |
Despite an increase in recent years, hepatocellular carcinoma remains uncommon in the Netherlands. The aim of the current study is to explore potential effects of hospital type and volume on outcomes after resection or sorafenib in patients with hepatocellular carcinoma.
Methods |
Initial treatment and survival of patients with hepatocellular carcinoma diagnosed in the period 2005–2011 were based on data of the Netherlands Cancer Registration. Potential risk factors (including hospital type and volume) for 30-days postoperative and long-term mortality in patients who underwent resection and in patients treated with sorafenib were evaluated by uni- and multivariate analyses.
Results |
In the period 2005–2011, 2402 patients were diagnosed with hepatocellular carcinoma: 12% received resection and 9% sorafenib. Postoperative mortality was higher in non-university hospitals (13% versus 4%; P=0.01). Resection in non-university hospitals was associated with higher postoperative mortality (odds ratio 3.38, 95% confidence interval 1.37–10.68) and long-term mortality (hazard ratio 1.21, 95% confidence interval 1.04–1.40). Sorafenib treatment in non-university hospitals was also associated with higher long-term mortality (hazard ratio 1.39, 95% confidence interval 1.06–1.82). Hospital volume was not independent predictor for outcome.
Conclusion |
In low incidence countries, outcome after resection or sorafenib for hepatocellular carcinoma may differ between various hospital types.
Le texte complet de cet article est disponible en PDF.Plan
Vol 39 - N° 6
P. 725-735 - décembre 2015 Retour au numéro
Article précédent
- Efficacy and safety of photodynamic therapy for unresectable cholangiocarcinoma: A meta-analysis
- Yi Lu, Lei Liu, Jia-chuan Wu, Li-ke Bie, Biao Gong
- CD44v6 expression is associated with a poor prognosis in Chinese hepatocellular carcinoma patients: A meta-analysis
- Yong Fu, Ying Geng, Ning Yang, Nan Zhu, Chang-Zheng Wang, Xin-Cheng Su, Hai-Bin Zhang
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?