Misdiagnosis may result from biopsy site selection, technique, or choice of transport media. Important potential sources of error include false-negative direct immunofluorescence results based on poor site selection, uninformative biopsy specimens based on both site selection and technique, and spurious interpretations of pigmented lesions and nonmelanoma skin cancer based on biopsy technique. Part I of this 2-part continuing medical education article addresses common pitfalls involving site selection and biopsy technique in the diagnosis of bullous diseases, vasculitis, panniculitis, connective tissue diseases, drug eruptions, graft-versus-host disease, staphylococcal scalded skin syndrome, hair disorders, and neoplastic disorders. Understanding these potential pitfalls can result in improved diagnostic yield and patient outcomes.Le texte complet de cet article est disponible en PDF.
Key words : basal cell carcinoma, bullous diseases, connective tissue diseases and porphyria, cutaneous T-cell lymphoma, dermatofibrosarcoma protuberans, hair disorders, malignant melanoma, neoplasms, panniculitis, primary cutaneous B-cell lymphoma, staphylococcal scalded skin syndrome, squamous cell carcinoma, Stevens–Johnson syndrome, toxic epidermal necrolysis, vasculitis
| Funding sources: None.
| Conflicts of interest: None declared.
| Reprints not available from the authors.
| Date of release: January 2016
| Expiration date: January 2019