Pleiotropic effects of insulin and GLP-1 receptor agonists: Potential benefits of the association - 08/01/16
Abstract |
The combination of basal insulin and glucagon-like peptide-1 receptor agonists (GLP-1RAs) is an emerging option for patients with type 2 diabetes (T2D). GLP-1RAs have been shown to improve glycaemic control with a low risk of hypoglycaemia and to promote body weight loss. However, GLP-1 receptors (GLP-1Rs) are widely expressed in extrapancreatic tissues and could sustain pleiotropic actions of GLP-1RAs beyond glycaemic control. The underlying molecular mechanisms maintaining these extrapancreatic actions of GLP-1 are complex, and involve GLP-1R signalling in both the brain and several peripheral tissues. The present review focuses specifically on the role of GLP-1RAs in the cardiovascular system and liver. Preclinical data in rodents and pilot studies in humans suggest that GLP-1RAs may have potential beneficial effects on heart function, blood pressure, postprandial lipaemia, liver steatosis and non-alcoholic steatohepatitis (NASH). Long-term studies are now warranted to determine the safety and clinical relevance of the association between insulin and GLP-1RAs in T2D.
Le texte complet de cet article est disponible en PDF.Keywords : Exenatide, Liraglutide, Lixisenatide, NASH, Cardiovascular, Heart, Liver
Plan
Vol 41 - N° 6S1
P. 6S28-6S35 - décembre 2015 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.