Evaluation of gender differences in early outcomes after ST-elevation Acute Myocardial Infarction (STEMI) in different age groups of patients following percutaneous coronary interventions (PCI).

We studied consecutive 292 female and consecutive 311 male STEMI patients who underwent PCI with stent implantation. Study individuals were divided into groups by the gender and age (<65, 65-75, >75 years). Patients with total ischemic time >4 hours were excluded from the study. In hospital and 45-days outcomes (death from cardiovascular causes, repeated angiography and revascularization) were evaluated.

Death in hospital and during 45-days period: total in women −0.168, 0.250, in men −0.161, 0.289, 0. differences were not significant (p>0.05). In hospital death rate in age groups <65, 65-75, >75years: in women −0.112, 0.155, 0.257, in men −0.121, 0.176, 0.216, 45-day mortality in women −0.135, 0.279, 0.338, in men −0.226, 0.279, 0.471. Differences are statistically significant in age group under 65 years (P<0.05). Age under 65 years is associated with lower probability of in hospital and 45 days mortality (OR −0.53, 95% CI 0.9 −0.25, OR- 0.36, 95% CI 0.18-0.72) in females, as well as with 45 days mortality in males OR-0.35, 95% CI 0.59-0.99. Study showed significantly (P<0.005) higher rate of repeated angiography (0.154 vs 0.077) and revascularization (0.127 vs 0.026) in females as compared with men after STEMI following primary PCI with stent implantation.

a) Mortality rates (in hospital and 45 days) after STEMI in patients with ischemic time < 4 hours who underwent PCI with stent implantation did not differ between genders; b) Women younger 65 years with STEMI after timely revascularization have better prognosis as compared with their male counterparts and females of other groups; c) Risk of repeated angiography and revascularization is higher in female patients with STEMI following primary PCI with stent implantation.