P-087: Effect of changing the type of fat on markers of cardiometabolic risk in obese rat - 12/02/16
Effet du changement du type de graisse sur les marqueurs de risque cardiométabolique chez le rat obèse
Résumé |
Background |
The purpose of this study is to verify if replacing margarine by sardine oil attenuates lipid peroxidation and improves reverse cholesterol transport in obese rats.
Methods |
Obesity was induced by feeding a high-fat-diet during 3 months. At 400±10g the obese rats (n=24) were divided into 2 groups and consumed during 1 month (d30) 20% margarine or sardine oil. At d30, 6 rats from each group were sacrificed and the remaining rats were then subjected to a change in diet for 1 month (d60): margarine was replaced by sardine oil and inversely.
Results |
The substitution of sardine oil by margarine enhanced cholesterol -very low density lipoprotein (C-VLDL) (+21%) and C-low density lipoprotein (LDL-HDL1) (+17%) and decreased C-high density lipoprotein (HDL2 and HDL3) subfractions by 38% and 15%, respectively. Indeed, lipid peroxidation was enhanced in LDL-HDL1 (+26%) and HDL2 and HDL3 (+41%). When margarine was replaced by sardine oil, C-VLDL, C-LDL-HDL1, C-HDL2 concentrations were deceased by –58, –81 and –35%, respectively and lecithin: cholesterol acyltransferase (LCAT) activity was significantly higher (+74%). Indeed, HDL2 and HDL3 lipid peroxidation was decreased respectively by 28% and 14%.
Conclusions |
In obese rats, the replacement of sardine oil by margarine seems to increase atherogenic markers and lipoperoxidation and consequently seemed to enhance cardiovascular diseases. However, the substitution of margarine by sardine oil can reduce lipid peroxidation and improves reverse cholesterol transport by increasing the activity of LCAT and thus ensuring a fortification in HDL2 cholesteryl esters. Sardine oil compared to margarine may have a protective effect against cardiovascular risk by improving the anti-atherogenic metabolic pathway of cholesterol.
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Vol 64 - N° S1
P. S53 - décembre 2015 Retour au numéro
Article précédent
- P-086: Donor age, warm ischemia time, and immunosuppressive drugs modify arterial stiffness in renal transplantation
- P. D'Halluin, S. Bertin, P. Gatault, C. Barbet, H. Longuet, J. Marliere, E. Merieau, B. Sautenet, C. Baron, M. Buchler, J.-M. Halimi
- P-088: Assessment of cardiac penalty payment among firefighters (Algeria's experience)
- M. Djazouli, D.D. Batouche, N. Benatta, M. Zegagh, C.B. Tebboune
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