P-166: Involvement of metalloproteinases and their inhibitors in vascular remodeling in hypertensive patients - 12/02/16
Implication des metalloprotéinases et leurs inhibiteurs dans le remodelage vasculaire chez des patients hypertendus
Résumé |
Background |
The aim of this study was to determine the plasma levels of Matrix metalloproteinases (MMPs): MMP-2, MMP-3, MMP-9, and their inhibitors (TIMPs): TIMP-1, and TIMP-2 in hypertensive patients and healthy subjects
Methods |
The study has involved 60 hypertensive patients and 61 adult healthy controls. Activity of pro-MMP-9 and pro-MMP-2, was carried by gelatin zymography method and MMP-3, TIMP-1, and TIMP-2 levels were determined by ELISA methods.
Results |
The mean plasma activity of pro-MMP-9 in the hypertensive group and the control group were significantly different (153.33±129.33 vs 90.38±97.49x103 densitometric units/μl; p<0.01). The plasma concentration of MMP-3 was significantly higher in hypertensive subjects then healthy subjects (20.24±8.63 vs 16.41±6.8ng/ml; p<0.05). Whereas the plasma concentration of TIMP-1 in the hypertensive group was lower than that in the control group 88.96±26.9 vs 93.96±27.28ng/ml. The MMP-3/TIMP-1 and the MMP-3/TMP-2 ratios were higher in hypertensive subjects than healthy subjects. We found significant positive correlation between systolic blood pressure and pro-MMP-9 (r=0.311, p<0.001).
Conclusions |
The present study identified abnormalities in plasma markers for extracellular matrix metabolism in hypertensive patients.
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Vol 64 - N° S1
P. S78 - décembre 2015 Retour au numéro
Article précédent
- P-165: Protective role of nucleotidases against the development of hypertension
- C. Roy, Al. Guihot, B. Toutain, J. Sevigny, D. Henrion, G. Kauffenstein
- P-167: Hypertension resistant revealing a renovascular stenosis of a solitary kidney
- R. Bouchair, C. Yousfi, H. Kaghouche, S. Ouarets, Y. Benchaabi, R. Belguedj, N. Djeghri, A. Ghouati, F. Teniou, H. Ghediri, D.R. Belouahed
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