P-210: Effect of pectin extract of date (phoenix dactylifera) against lead neurotoxicity: neurobehavioral study - 12/02/16
L'effet des pectines extraites de datte (phoenix dactylifera) contre la neurotoxicité du plomb:étude neurocomportementale
Résumé |
Background |
Lead is a neurotoxicant with known behavioral and neurochemical effects, is causing oxidative burst in the exposed individuals leading to brain damage. In previous work, we reported that ingestion a pectin of date (Phoenix Dactylifera) may decrease effect toxic of this heavy metal, Here, we evaluated the potential detoxifying effect of pectin after oral Pb exposure in males rats.
Methods |
Purpose, the young rats received for 30 days of lead acetate by gavage, the treatment with pectin of date started after one month of intoxication
Results |
Oral administration of pectin after intoxication with lead acetate caused a lower locomotor activity as observed in the open field test which was higher in rat exposed by lead only, while for the dark and light test we had observed a decrease in the time past in dark room of exposed rat compared to the control, while the treatment with pectin extract of date enhance the time past in light room and increase the time in obscure room which represent a depression behavior. Therefore, pectin of date provided a significant protection to thiobarbituric acid reactive substances (TBARS) level in brain, while cause a decrease in catalase and phosphatase alkalin (PAL) levels
Conclusions |
Our results showed chelator effect of pectin on lead toxicity poisoning
Le texte complet de cet article est disponible en PDF.Vol 64 - N° S1
P. S93 - décembre 2015 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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