0093: Early and late outcomes after trans-catheter aortic valve implantation in patients with previous thoracic irradiation - 12/02/16
Résumé |
Background |
Thoracic radiation therapy exposes to aortic stenosis and surgery is associated with high orbid-mortality rates. Trans-catheter aortic valve implantation (TAVI) may represent an interesting alternative, but experience remains limited in this setting. We compared late outcome in a Radiation group and a matched population undergoing TAVI and identified predictive factors of late survival.
Methods |
Between October 2006 and April 2011, 288 consecutive patients underwent TAVI in our institution, of whom 27 had previous chest radiation. They were matched 1:1 on age, sex and TAVI approach with a control population.
Results |
Mean age was 72±13 years in the Radiation group versus 75±9 in the control group (p=0.52), 48% were male and 15% had a trans-apical approach. Procedural success was 89% (n=24) in the Radiation group versus 96% (n=26) in controls and 30-day survival was 93±5% in both groups. Follow-up was complete in all patients (median 3.4; interquartile range [2.6– 4.2] years). Five-years survival rates were 32±10% in the Radiation group and 41±11% in controls (p=0.27). In Radiation group, the cause of death was respiratory failure secondary to radiation-induced fibrosis or sepsis in 54% of cases. In multivariate analysis, we identified 3 predictive factors of late death in Radiation group: 1 pre-procedural variable: the absence of Beta-blockers therapy (HR=36.3 [4.1–325.2], p=0.001), and 2 post-procedural variables: creatinine peak (HR=1.04 [1.02-1.07], p<0.0001) and infectious complication (HR=7.8 [1.7-36.0], p=0.009). In the radiation group, 89% of survivors were in NYHA class I-II at last follow-up.
Conclusion |
Patients of the Radiation group displayed high mortality rates even though not significantly different from the control population. In patients with radiation valvular disease, the use of B-blockers was an independent predictor of late survival after TAVI which deserves further consideration. Moreover, respiratory failure was the main cause of death, emphasizing the need for a careful pulmonary evaluation. Finally, we show a sustained improvement in functional results after TAVI in this particular population.
Le texte complet de cet article est disponible en PDF.Vol 8 - N° 1
P. 58 - janvier 2016 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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