Onychomycosis is a fungal infection of nails primarily caused by dermatophyte fungi. Fungi are traditionally understood as existing in the environment as planktonic organisms; however, recent advancements in microbiology suggest that fungi form biofilms–complex sessile microbial communities irreversibly attached to epithelial surfaces by means of an extracellular matrix. The extracellular matrix also acts as a protective barrier to the organisms within the biofilm. The biofilm is surprisingly resistant to injury and may act as a persistent source of infection possibly accounting for antifungal resistance in onychomycosis.Le texte complet de cet article est disponible en PDF.
Key words : antifungal, biofilm, dermatophyte fungi, extracellular matrix, nail, onychomycosis
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| Disclosure: Dr Gupta has been a consultant for Anacor, Sandoz, and Moberg Pharma; been a clinical trials investigator for Valeant Canada, Nuvolase, Bristol Meyers Squibb, Eli Lilly, Merck, Novartis, Janssen, and Allergan; and served as a speaker for Valeant Canada, Janssen, Novartis, and Bayer. Ms Daigle and Dr Carviel are previous and present employees of Mediprobe Research Inc, which conducted the above trials.