Evaluation of dermoscopic features for distinguishing melanoma from special site nevi of the breast - 20/07/16
Abstract |
Background |
Nevi of special sites display aberrant clinical and histologic features that can be difficult to distinguish from melanoma, leading to unnecessarily high rates of excision with poor cosmetic or functional results. Dermoscopy can improve clinical assessment of melanocytic lesions by visualizing morphologic structures beyond the epidermis.
Objective |
We sought to assess the value of specific dermoscopic features for diagnosing melanocytic neoplasms arising on the breast area in females.
Methods |
In this retrospective cohort study, we collected clinical and dermoscopic information for 104 nevi and 13 melanomas removed from the breast, chest, and areola, and evaluated the diagnostic performance of each dermoscopic feature.
Results |
Melanomas from the breast area were larger (P = .0175) than nevi and occurred in older women (P = .0117). Irregular blotches, nonuniform radial streaks, blue-gray veil, and regression were highly specific for melanoma, whereas atypical network and irregular dots and globules had low to moderate specificity.
Limitations |
This study was retrospective with a small sample size.
Conclusion |
Compared to melanocytic neoplasms from other sites, atypical network and irregular dots and globules were poor indicators for breast melanoma. Irregular blotches, nonuniform radial streaks, blue-gray veil, and regression were highly specific and should heighten clinical suspicion for melanoma arising on the breast.
Le texte complet de cet article est disponible en PDF.Key words : breast, dermatopathology, dermoscopy, malignant melanoma, nevi of special sites, pattern analysis
Plan
Supported by the IDP Foundation. |
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Disclosure: Dr Martini served on the advisory board of Dove-Unilever and received honoraria for this. Dr Gerami served as a consultant to Castle Biosciences Inc, Myriad Genetics, and DermTech Inc, and received honoraria for this. Ms Merkel, Dr Amin, and Ms Lee have no conflicts of interest to declare. |
Vol 75 - N° 2
P. 364-370 - août 2016 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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