Evaluation of anti-osteoporotic activity of butanolic fraction from Passiflora foetida in ovariectomy-induced bone loss in mice - 13/03/17
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Highlights |
• | Butanolic fraction of Passiflora foetida improves bone micro architecture in mice after oral administration for 8 weeks. |
• | Indicative bone anabolic action with enhanced bone formation rate compared with the ovariectomized group. |
• | Enhanced the expression of osteogenic genes and decreased the expression of osteoclastogenic genes in ovariectomized group. |
• | Bone-sparing action was also corroborated with serum bone markers like OCN and CTx. |
• | Data suggest, BF administration is safe for use in postmenopausal osteoporosis, devoid of harmful effects in uteri. |
Abstract |
Objective |
In this study, we have evaluated the skeletal effects of butanolic fraction (BF) from Passiflora foetida in an estrogen deficient mice bone loss model.
Study design |
Skeletal effect of BF was studied in ovariectomized (OVx) female Balb/c mice. BF (50 and 100mg/kg/day dose orally) was given for 8 weeks. Micro-architecture of long bones, biomechanical strength, formations of mineralized nodule by bone marrow osteoprogenitor cells, osteoid formation and bone turnover markers were studied. One way ANOVA was used to test the significance of effects of Passiflora foetida.
Results |
OVx mice treated with BF represented with better micro-architectural parameters at various anatomical positions, better bone biomechanical strength and more osteoprogenitor cells in the bone marrow compared with OVx group. BF did not exhibit uterine estrogenicity.
Conclusion |
Oral administration of BF at both the doses (50 and 100mg/kg/day) derived from Passiflora Foetida, was found to afford anti-osteoporotic effect under estrogen deficiency by likely stimulation of osteoblast function and inhibition of osteoclast function.
Le texte complet de cet article est disponible en PDF.Keywords : Ovariectomy, Osteogenic, Estrogenicity, Trabecular microarchitecture, Microcomputed tomography
Plan
Vol 88
P. 804-813 - avril 2017 Retour au numéro
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