Dysplastic nevi with severe atypia: Long-term outcomes in patients with and without re-excision - 18/04/17
Abstract |
Background |
Dysplastic nevi with severe atypia (severely dysplastic nevi [SDN]) are frequently re-excised because of the concern that these lesions may in fact represent early melanoma. Data on long-term follow-up of these patients are limited.
Objective |
We sought to determine the rate of subsequent melanoma development in patients with SDN who underwent re-excision versus those who did not and to determine factors associated with decision to re-excise.
Methods |
A retrospective single institutional study was conducted with 451 adult patients (mean age 41.3 years) with SDN biopsied between November 1994 and November 2004, with clinical follow-up of at least 5 years.
Results |
In 451 patients with SDN, re-excision was performed on 36.6%. Two melanomas were diagnosed in the re-excision specimens. Subsequent metastatic melanoma developed in 7 patients, all of whom had a history of melanoma. Margin comments influenced decision to re-excise.
Limitations |
This was a retrospective study at a single institution.
Conclusion |
Re-excision of all SDN may not be necessary.
Le texte complet de cet article est disponible en PDF.Key words : dysplastic, melanoma, nevus, pigmented lesion, re-excision, severe atypia
Plan
Drs Engeln and Peters contributed equally to this article. |
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Funding sources: None. |
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Disclosure: Dr Ferris has been an investigator and consultant for DermTech International and Castle Biosciences. Drs Engeln, Peters, Ho, Jedrych, and Patton; and Mr Winger have no conflicts of interest to declare. |
Vol 76 - N° 2
P. 244-249 - février 2017 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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