Mucosal melanomas in the racially diverse population of California - 18/04/17
, Michael K. Wong, MD, PhD c, David H. Peng, MD, MPH a, Myles Cockburn, PhD a, bAbstract |
Background |
Mucosal melanomas are rare, poorly understood neoplasms without a consensus standard of care.
Objective |
We sought to define mucosal melanoma tumor characteristics and the racial/ethnic attributes of patients with mucosal melanomas.
Methods |
We analyzed 130,920 cutaneous melanomas and 1919 mucosal melanomas recorded in the population-based California Cancer Registry from 1988 to 2013.
Results |
Although only 1% of melanomas occurring in nonHispanic whites were mucosal, other racial/ethnic groups had a higher proportion of mucosal melanomas (15% for Asian/Pacific Islanders, 9% for nonHispanic blacks, and 4% for Hispanics). Anorectal mucosal melanomas were most common in female Asian/Pacific Islanders, whereas genitourinary mucosal melanomas were highest in nonHispanic whites, and head and neck tumors were most common among Hispanics. Stage at presentation was not uniform among racial/ethnic groups, with Asian/Pacific Islanders having the highest rates of metastasis.
Limitations |
The lack of a standardized staging system for mucosal melanomas confounds classification and knowledge regarding metastasis. Small sample size limits comparative analysis across race, stage, site, and depth.
Conclusion |
Mucosal melanomas differ by race/ethnicity with regard to anatomic site, stage, and depth. Because early detection offers the best chance of increased survival, greater awareness will aid clinicians who care for patients at risk for these aggressive tumors.
Le texte complet de cet article est disponible en PDF.Key words : California, extracutaneous melanoma, melanoma, melanoma detection, mucosal melanoma, population-based database, race/ethnicity, screening
Plan
| Dr Cockburn was supported in part by the National Cancer Institute's Surveillance, Epidemiology, and End Results Program under contract HHSN261201000140C awarded to the Cancer Prevention Institute of California, contract HHSN261201000035C awarded to the University of Southern California, and contract HHSN261201000034C awarded to the Public Health Institute; and the Centers for Disease Control and Prevention's National Program of Cancer Registries, under agreement U58DP003862-01 awarded to the California Department of Public Health. |
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| Conflicts of interest: None declared. |
Vol 76 - N° 2
P. 250-257 - février 2017 Retour au numéro
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