Palladium-catalyzed regioselective direct C-H arylation of pyrazolo[3,4-d]pyrimidines - 02/08/17
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Abstract |
Nitrogenous bicycles are an apparently endless field of organic and biological research. In this study, we disclose an efficient pathway to the synthesis of the pyrazolo[3,4-d]pyrimidine scaffold in three steps from allopurinol. This key intermediate was engaged in the first example of regioselective C-H arylation catalyzed by palladium to access a library of 3-substituted-1-methyl-4-phenyl-1H-pyrazolo[3,4-d]pyrimidines.
Le texte complet de cet article est disponible en PDF.Keywords : Nitrogenous bicycles, 1H-Pyrazolo[3,4-d]pyrimidines, C–H arylation, Regioselectivity, 1,10-Phenanthroline, Palladium
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